Reply to prognosis of sentinel lymph node biopsy in patients with thick melanoma by a propensity score matching prospective study

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Crystallinity and microstructural versatility in the spin-crossover polymeric material [Fe(Htrz)2(trz)](BF4)

The room-temperature microstructure of the spin-crossover (SCO) 1D-polymeric iron(II) compound [Fe(Htrz)2(trz)](BF4) is investigated by mean of powder X-ray diffraction and compared to the SCO features determined by magnetic measurements. The determination of the microstructural parameters such as the sizes of the coherent domains and their morphologies for many samples reveals new features for this material. First, a heating treatment can significantly improve the crystallinity of the material by doubling the coherent domains size. This result may open the route to regenerating this system after the reported mechanical fatigue it undergoes after suffering numerous SCO cycles. In addition, the correlation between the length of the coherent domain and the SCO temperature shows a tendency: the longer the domains - i.e. the longer the iron chains - the higher the SCO temperatures.

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Natural Bioactive Compounds: Alternative Approach to the Treatment of Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most frequent, primary malignant brain tumor prevalent in humans. GBM characteristically exhibits aggressive cell proliferation and rapid invasion of normal brain tissue resulting in poor patient prognosis. The current standard of care of surgical resection followed by radiotherapy and chemotherapy with temozolomide is not very effective. The inefficacy of the chemotherapeutic agents may be attributed to the challenges in drug delivery to the tumor. Several epidemiological studies have demonstrated the chemopreventive role of natural, dietary compounds in the development and progression of cancer. Many of these studies have reported the potential of using natural compounds in combination with chemotherapy and radiotherapy as a novel approach for the effective treatment of cancer. In this paper, we review the role of several natural compounds individually and in combination with chemotherapeutic agents in the treatment of GBM. We also assess the potential of drug delivery approaches such as the Gliadel wafers and role of nanomaterial based drug delivery systems for the effective treatment of GBM.

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Correction to: Pentachlorophenol Biodegradation by Citrobacter freundii Isolated from Forest Contaminated Soil

Abstract

One of the bibliographic reference entry of this article had the author name and family name switched by mistake.

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The Genetic Basis of Seborrheic Dermatitis: A Review

Abstract

Seborrheic Dermatitis (SD) is a common inflammatory skin disease that presents as itchy, flaking skin in the seborrheic areas. Various environmental and intrinsic factors have been identified as predisposing factors for SD, but its etiology remains poorly understood. Although it was recognized that genetic factors play a role in SD etiology, there have not been studies that systematically review the literature specifically for causal mutations or protein deficiencies in SD. In this review, we searched various databases for gene mutations and protein deficiencies that cause SD or SD-like phenotype in humans and experimental animals, and summarize 11 gene mutations or protein deficiencies that were described in the literature. Most of the encoded proteins play a role either in the immune response (ACT1, C5, IKBKG/NEMO, STK4, 2C TCR) or epidermal differentiation (ZNF750, MPZL3). Understanding the genetic basis of SD can impart knowledge of the pathobiology of the disease and help identify novel therapeutic targets.

This article is protected by copyright. All rights reserved.

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IJMS, Vol. 18, Pages 2436: Calcium-Dependent Protein Kinases in Phytohormone Signaling Pathways

IJMS, Vol. 18, Pages 2436: Calcium-Dependent Protein Kinases in Phytohormone Signaling Pathways

International Journal of Molecular Sciences doi: 10.3390/ijms18112436

Authors: Wuwu Xu Wenchao Huang

Calcium-dependent protein kinases (CPKs/CDPKs) are Ca2+-sensors that decode Ca2+ signals into specific physiological responses. Research has reported that CDPKs constitute a large multigene family in various plant species, and play diverse roles in plant growth, development, and stress responses. Although numerous CDPKs have been exhaustively studied, and many of them have been found to be involved in plant hormone biosynthesis and response mechanisms, a comprehensive overview of the manner in which CDPKs participate in phytohormone signaling pathways, regulating nearly all aspects of plant growth, has not yet been undertaken. In this article, we reviewed the structure of CDPKs and the mechanism of their subcellular localization. Some CDPKs were elucidated to influence the intracellular localization of their substrates. Since little work has been done on the interaction between CDPKs and cytokinin signaling pathways, or on newly defined phytohormones such as brassinosteroids, strigolactones and salicylic acid, this paper mainly focused on discussing the integral associations between CDPKs and five plant hormones: auxins, gibberellins, ethylene, jasmonates, and abscisic acid. A perspective on future work is provided at the end.

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Lung necrosectomy in pediatric patients with necrotizing pneumonia

Abstract

Introduction

Necrotizing pneumonia is the consolidation of lung parenchyma with destruction and necrosis, forming solitary or multiloculated radiolucent foci. When antibiotic treatment fails and clinical course does not improve, patients might need lung tissue resection: segmentectomy, lobectomy or bilobectomy. We have performed a more conservative surgical approach in pediatric patients with necrotizing pneumonia, lung necrosectomy: resection of unviable necrotic tissue, to preserve more healthy and potentially recoverable lung parenchyma. The objective of this study is to present the results of our experience with lung necrosectomy.

Methods

Retrospective review of clinical charts of children with necrotizing pneumonia. The diagnosis was based on physical examination, laboratory data and contrast CT scan. Lung necrosectomy technique includes resection of necrotic tissue with careful debridement technique; air leaks were sutured and/or tissue imbrication.

Results

Twenty-four children were surgically treated for necrotizing pneumonia (18 girls and 6 boys). The mean age was 31.5 ± 13.5 months. All the patients presented productive cough, fever and dyspnea; chest X-rays showed consolidated areas with intraparenchymal cavities and hypoperfusion on the contrasted CT. Surgical treatment included: Lung necrosectomy 17 (70%); lobectomy 3 (12.5%); wedge resection 2 (8.3%); lobectomy + lung necrosectomy 1 (4.1%), and wedge resection + lung necrosectomy 1 (4.1%). The postoperative course was uneventful in 23 patients; mean postoperative hospital stay was 6.3. One patient died because of sepsis.

Conclusions

Lung necrosectomy is a conservative, effective surgical treatment, which solves lung necrotizing infection avoiding resection of healthy lung parenchyma.

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