Noninvasive measures in atopic dermatitis

Purpose of review To summarize the current knowledge on the morphology, functionality and biochemical composition of the skin in allergic reactions. We address novel noninvasive techniques that promise to disclose intimate mechanisms of skin allergy in vivo. Epidermal barrier is not just a static wrap of the organism but rather a dynamic field for immunological, biophysical and biochemical processes and serves as a bio-sensor for exogenous danger signals. Recent findings Classical biophysical methods are amended by novel in-vivo techniques, such as Raman spectroscopy, analysing the skin microcomposition and develop epidermal profiles. Visualization techniques, such as reflectance spectroscopy and optical coherence tomography (OCT) are employed in studying the micro-morphological changes in the skin of allergic patients. Summary The noninvasive assessment of skin functions, micro-morphology and biochemical as well as immunological pathways will help to better understand skin allergies. They will allow to detect subtypes, for example in atopic dermatitis and to develop specific treatment modalities. Correspondence to Joachim W. Fluhr, Charite Universitätsmedizin Berlin, Department of Dermatology and Allergy, Charitéplatz 1, 10117 Berlin, Germany. E-mail: Joachim.fluhr@charite.de Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease

Viral Immunology, Ahead of Print.


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Plasma Kallistatin Levels in Children with Community-Acquired Pneumonia

Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.


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Plasma Kallistatin Levels in Children with Community-Acquired Pneumonia

Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.


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Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report

Medullary thyroid carcinoma and pituitary adenoma are neuroendocrine tumors and their coexistence has not been reported in the literature, previously. Medullary thyroid carcinoma is a neoplasm of the thyroid g...

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Stem Cells in Dermatology and Anti-aging Care of the Skin

Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Various studies characterizing dermatologic stem cell populations and its coordination with one another during wound healing have uncovered how these components can act as a skin aging therapy.

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Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss

The current state of the applicability of cell therapy for the treatment of various conditions of hair loss reveals a promising and potentially effective role. Further research, based on published work to date, is indicated to further explore the potential roles of autologous fat grafting, mesenchymal stem cells, and stromal vascular fraction therapy. The authors' evolving experience matches these promising scientific findings.

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