Local production of prolactin in lesions may play a pathogenic role in psoriatic patients and imiquimod‐induced psoriasis‐like mouse model

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nNVVRL

Role of IL‐17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2wdRiEz

Autoantibody to transcriptional intermediary factor‐1β as myositis‐specific antibody: clinical correlation with CADM or DM with mild myopathy

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MA6YfC

Impact of Hidradenitis Suppurativa on Work Loss, Indirect Costs and Income

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2N1iTA6

Skin resident memory T cell population is not effectively constructed in systemic sclerosis

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MugIIj

Long‐term 52‐week trends in apremilast safety outcomes for treatment of psoriasis in clinical practice: a multicentre, retrospective case series

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2BxkIDE

Monitoring of patients with metastatic melanoma treated with immune checkpoint inhibitors using PET–CT

Abstract

Immune checkpoint inhibitors (ICI) have revolutionized therapy of metastatic melanoma. The first ICI was ipilimumab, a cytotoxic T lymphocyte-associated Ag 4 (CLTA-4) inhibitor with response rates of approximately 11% and disease control of 22%. The programmed cell death 1 (PD-1) inhibitors, such as pembrolizumab and nivolumab, led to longer progression-free survival and overall survival rates with fewer side effects. Molecular imaging techniques, such as positron emission tomography–computed tomography (PET–CT) with 2-deoxy-2-(¹⁸F)fluoro-d-glucose (¹⁸F-FDG) are in use for staging and therapy monitoring of metastatic melanoma. However, classical radiological imaging criteria such as RECIST and WHO are not appropriate for the assessment of ICI response. New immune-related criteria have been defined such as iRECIST or irRC, which refer to radiological imaging modalities. Until now only a few studies report on immunotherapy response assessment based on ¹⁸F-FDG PET–CT. The classical criteria used for therapy monitoring with ¹⁸F-FDG PET, such as the EORTC criteria, are not suitable for ICI monitoring. In this focussed review, we present different criteria proposed for ICI monitoring with ¹⁸F-FDG and their limitations. One goal is to early identify non-responders to tailor immunotherapy. Another question is pseudoprogression and how to interpret the ¹⁸F-FDG images for response assessment. Finally, the definition of ¹⁸F-FDG criteria which can be used to identify progress is crucial and discussed in the review. The recent presented PET-based immune-related criteria, the so-called PERCIMT (PET Response Evaluation Criteria for IMmunoTherapy) are presented. Furthermore, new tracers are discussed.

https://ift.tt/2L507Ga