Outcomes following radiation for cutaneous squamous cell carcinoma of the head and neck: Associations between immune suppression and recurrence

Abstract

Background

Data evaluating outcomes and patterns of recurrence following radiation therapy (RT) for cutaneous squamous cell carcinoma (cSCC) of the head and neck are limited.

Methods

We performed a retrospective analysis of 111 head and neck cSCC patients treated with RT at 4 affiliated institutions.

Results

With median follow‐up of 7 months, there were 29 (26%) recurrences, 73% of which were nodal (n = 21). Immunosuppression (IS) was the only factor associated with recurrence (47% in IS, 22% in non‐IS, P = .04), and also with time to recurrence in multivariate analysis (HR 5.5; P = .03). No factors were associated with recurrence among patients who received definitive RT. The majority of patients who recurred were salvaged with surgery (n = 20, 69%).

Conclusion

In a cohort of cSCC treated with radiotherapy, there was an association between IS and increased failure risk. The majority of failures were salvaged surgically.

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The Political Economy of the Higher Education Contribution Scheme

Hicks, TM; Chapman, B; (2018) The Political Economy of the Higher Education Contribution Scheme. In: Cantwell, B and Coates, H and King, R, (eds.) Handbook on the Politics of Higher Education. (pp. 248-264). Edward Elgar: Cheltenham, UK. Green open access

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Devolution and Planning

Tomaney, J; Colomb, C; (2018) Devolution and Planning. In: Ferm, J and Tomaney, J, (eds.) Planning Practice: Critical Perspectives from the UK. (pp. 20-35). Routledge: New York, NY, USA.

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Planning for diversity in an era of social change

Colomb, C; Raco, M; (2018) Planning for diversity in an era of social change. In: Ferm, J and Tomaney, J, (eds.) Planning Practice: Critical Perspectives from the UK. (pp. 174-188). Routledge: New York, NY, USA.

http://bit.ly/2HRMcXN

Language and Translation in Film: Dubbing and Subtitling

Baños, R; Diaz-Cintas, J; (2017) Language and Translation in Film: Dubbing and Subtitling. In: Malmkjaer, K, (ed.) The Routledge Handbook of Translation Studies and Linguistics. (pp. 313-326). Routledge: London, UK.

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Withdrawn: Prenatal thoraco-amniotic chest drain insertion to manage a case of fetal hydrops secondary to FOXC2

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Prophylactic human papilloma virus vaccination in head and neck: indications and future perspectives

Purpose of review To gain the evidence-based knowledge concerning the efficacy of HPV vaccination for oropharyngeal sites and to highlight the trials and strategies for vaccine administration in HPV-dependent head and neck diseases. Recent findings Vaccination can be provided in two injections. There is increasing anecdotal evidence that therapeutic vaccination is effective in treatment of recurrent respiratory papillomatosis. Summary The availability and broadening spectrum of HPV vaccines make possible the prevention of cervical and other HPV-dependent diseases. Vaccination is now included in the national immunization programs of most industrial countries and will be used, it is hoped, in developing countries within the next few years. In developing countries, few women are screened for cervical precancerous lesions, making immunization even more important. In affluent countries and matured societies, with high coverage of cervical screening, the focus of interest will shift to other HPV-related diseases. The HPV vaccination is effective in preventing oral infection with types targeted by the vaccines. Correspondence to Professor Frederik G. Dikkers, MD, PhD, Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Tel: +31 20 566 3789; e-mail: f.g.dikkers@amc.nl Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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