Computer Speech & Language,Evaluating the State-of-the-Art of End-to-End Natural Language Generation: The E2E NLG ChallengePublication date: Available online 3 July 2019Source: Computer Speech & LanguageAuthor(s): Ondřej Dušek, Jekaterina Novikova, Verena RieserAbstractThis paper provides an comprehensive analysis of the first shared task on End-to-End Natural Language Generation (NLG) and identifies avenues for future research based on the results. This shared task aimed to assess whether...
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Faisabilité et bénéfices de la formation au dépistage du trouble ventilatoire obstructif Thu Jul 04, 2019 17:29via ScienceDirect Publication Revue des Maladies RespiratoiresTranslate articleelsevier-non-solus.pngPublication date: Available online 3 July 2019Source: Revue des Maladies RespiratoiresAuthor(s): N. Pennequin, P. Léger, N. Freymond, N. Coullandaye, D. Poupon, É. Tranchard, O. Cuoq, Y. PachecoRésuméIntroductionBien qu'encore sous-diagnostiquée, la bronchopneumopathie chronique obstructive...
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PREP2 Algorithm Predictions Are Correct at 2 Years Poststroke for Most Patients.04:16by Smith MC, Ackerley SJ, Barber PA, Byblow WD, Stinear CM via pubmed neurorehabil neural...Related ArticlesPREP2 Algorithm Predictions Are Correct at 2 Years Poststroke for Most Patients.Neurorehabil Neural Repair. 2019 Jul 03;:1545968319860481Authors: Smith MC, Ackerley SJ, Barber PA, Byblow WD, Stinear CMAbstractBackground. The PREP2 algorithm combines clinical and neurophysiological measures to predict upper-limb...
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Bone biology in postnatal Wistar rats following hypoxia-reoxygenation.Thu Jul 04, 2019 16:19by Hameister R, Lohmann CH, Dheen ST, Singh G, Kaur C via Cellular and Molecular BiologyBone biology in postnatal Wistar rats following hypoxia-reoxygenation.Histol Histopathol. 2019 Jul 03;:18143Authors: Hameister R, Lohmann CH, Dheen ST, Singh G, Kaur CAbstractHypoxia response pathways have a central role in normal and abnormal bone biology but the effect of systemic hypoxia-reoxygenation on bone is not...
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Clinical Oral Investigations,Effect of cavity lining on the restoration of root surface carious lesions: a split-mouth, 5-year randomized controlled clinical trialAbstract Objective To compare the clinical performance of cavities with no lining and lining with resin-modified glass ionomer (RMGIC) for the treatment of root surface carious lesions. Materials and methods The study included 39 patients (mean age, 39.6 years) who visited the university hospital for the treatment of at least 2 root surface...
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Transcranial Doppler as a non-invasive method to estimate cerebral perfusion pressure in children...
Transcranial Doppler as a non-invasive method to estimate cerebral perfusion pressure in children with severe traumatic brain injuryvia Latest Results for Child's Nervous SystemAbstractIntroductionCerebral perfusion pressure (CPP) is one of the most important parameters in preventing ischemic brain insults. Guidelines have used CPP values to guide treatment of traumatic brain injury (TBI) for many years. We tested the feasibility of a novel non-invasive method for CPP estimation (nCPP) in children...
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Intravenous Stem Cell Therapy for High-Grade Aneurysmal Subarachnoid Hemorrhage: Case Report and Literature Reviewvia World NeurosurgeryPublication date: August 2019Source: World Neurosurgery, Volume 128Author(s): Marie-Christine Brunet, Stephanie H. Chen, Priyank Khandelwal, Joshua M. Hare, Robert M. Starke, Eric C. Peterson, Dileep R. YavagalBackgroundAneurysmal subarachnoid hemorrhage (SAH) is associated with high mortality (30%–40%) and morbidity with long-term physical, neurologic, and psychological...
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Waveform Complexity: A New Metric for EEG Analysisvia Journal of Neuroscience MethodsPublication date: Available online 3 July 2019Source: Journal of Neuroscience MethodsAuthor(s): Dhanya Parameshwaran, Narayan P. Subramaniyam, Tara C. ThiagarajanAbstractBackgroundEEG represents a cost-efficient mechanism to evaluate brain function. To realize this potential, it is essential to identify aspects of the signal that provide insight into differences in cognitive, emotional and behavioral outcomes and...
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Plasma total‐tau as a biomarker of stroke risk in the communityby Matthew P. Pase, Jayandra J. Himali, Hugo J. Aparicio, Jose Rafael Romero, Claudia L. Satizabal, Pauline Maillard, Charles DeCarli, Alexa S. Beiser, Sudha Seshadri via Annals of NeurologyAbstractHigher plasma total‐tau level is associated with incident dementia but its relationship with stroke risk is unknown. In this prospective community‐based study, we evaluated plasma total‐tau level as a biomarker of stroke risk in 2794 Framingham...
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Cerebellar mutism syndrome: current approaches to minimize risk for CMSvia Latest Results for Child's Nervous SystemAbstractPurposeCerebellar mutism syndrome (CMS) is a serious source of morbidity following posterior fossa surgery in the pediatric population. However, methods for effectively decreasing its incidence and impact remain unclear. It is our aim to examine the impact of adjusting surgical factors, namely the use of a telovelar approach and avoidance of cavitronic ultrasonic aspirator,...
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Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements [ADULT BRAIN] ...
Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements [ADULT BRAIN]by Galnares-Olalde, J. A., Vazquez-Mezquita, A. J., Gomez-Garza, G., Reyes-Vazquez, D., Higuera-Ortiz, V., Alegria-Loyola, M. A., Mendez-Dominguez, A. viaRadioSUMMARY:Consumption of over-the-counter dietary supplements to reduce body weight is common among the population. Thermogenics are herbal combinations that claim to produce a fat-burning process through an increase in the cellular metabolic rate...
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CT-Guided Block and Radiofrequency Ablation of the C2 Dorsal Root Ganglion for Cervicogenic Headache [SPINE]by Chazen, J. L., Ebani, E. J., Virk, M., Talbott, J. F., Shah, V. via RadioSUMMARY:The purpose of this report is to describe the technical aspects of CT-guided C2 dorsal root ganglion diagnostic block and radiofrequency ablation for refractory cervicogenic headache. CT guidance allows precise and safe positioning of a needle adjacent to the C2 dorsal root ganglion. At-risk neural and vascular...
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Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction-Based Testing [PEDIATRICS]by Sarma, A., Hanzlik, E., Krishnasarma, R., Pagano, L., Pruthi, S. via RadioSUMMARY:Human parechovirus infection is an increasingly recognized cause of neonatal meningoencephalitis. We describe characteristic clinical features and brain MR imaging abnormalities of human parechovirus meningoencephalitis in 6 infants. When corroborated by increasingly available polymerase chain reaction–based...
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Standardization of Temporal Bone CT Planes across a Multisite Academic Institution [HEAD & NECK]by Guenette, J. P., Hsu, L., Czajkowski, B., Nunez, D. B. via RadioBACKGROUND AND PURPOSE:Variable head positioning in the CT gantry results in variable and inconsistent temporal bone imaging planes. Our aim was to evaluate whether an automated postprocessing algorithm or an educational intervention with postprocessing by a technologist could result in consistent temporal bone image reformations into...
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Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy in Intracranial ICA Occlusion [INTERVENTIONAL]by Baek, B. H., Lee, Y. Y., Kim, S. K., Yoon, W. via RadioBACKGROUND AND PURPOSE:Predictors of outcome after endovascular thrombectomy have not been investigated adequately in patients with intracranial ICA occlusions. This study aimed to assess the impact of anterior choroidal artery infarction in pretreatment DWI on the outcome of patients with acute intracranial...
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World Neurosurgery,Andreas Vesalius, the Predecessor of Neurosurgery: How his Progressive Scientific Achievements Affected his Professional Life and DestinyPublication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Bruno Splavski, Krešimir Rotim, Goran Lakičević, Andrew J. Gienapp, Frederick A. Boop, Kenan I. ArnautovićAndreas Vesalius, the father of modern anatomy and a predecessor of neuroscience, was a distinguished medical scholar and Renaissance figure of the 16th Century...
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Radio, Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy...
Radio,Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy in Intracranial ICA Occlusion [INTERVENTIONAL]BACKGROUND AND PURPOSE:Predictors of outcome after endovascular thrombectomy have not been investigated adequately in patients with intracranial ICA occlusions. This study aimed to assess the impact of anterior choroidal artery infarction in pretreatment DWI on the outcome of patients with acute intracranial ICA occlusion who underwent thrombectomy.MATERIALS...
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Annals of Neurology, IL‐9 alterations linked to Alzheimer's disease in African Americans ABSTRACT...
Annals of Neurology,IL‐9 alterations linked to Alzheimer's disease in African AmericansABSTRACT Objective Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer's disease (AD), and lower cerebrospinal fluid (CSF) tau biomarker levels. It is not known whether tau‐related differences begin earlier in life, and whether race modifies other AD‐related biomarkers such as inflammatory proteins. Methods We performed multiplex cytokine analysis in a healthy middle‐aged...
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AntipsychoticsChlorpromazine Plasma levels may increase May need to decrease dose. Monitor forincrease in adverse effects.Clozapine Plasma levels may increase by72%.Reduce dose gradually over a week until75% of original dose. Repeat level.Consider further reductions.Clozapine +valproateEffect of stopping smoking inpatients who take bothclozapine & valproate may bemore marked then those onclozapine alone.Valproate inhibits clozapine metabolismin non-smokers (+16%)Valproate induces clozapine metabolismin...
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Medical HypothesesAvailable online 4 July 2019, 109302In Press, Accepted ManuscriptWhat are Accepted Manuscript articles?Author links open overlay panelThomasGuttusoJr.Co-Director, Movement Disorder Center, University at Buffalo, 3435 Main Street, 97 Farber Hall, Buffalo, NY 14214, United StatesReceived 27 April 2019, Accepted 3 July 2019, Available online 4 July 2019.https://doi.org/10.1016/j.mehy.2019.109302Get rights and contentAbstractParkinson's disease (PD) patients have higher rates of melanoma...
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Medical Hypotheses,Is Ulcerative Colitis a disease of a Dysfunctional Microbiota?Publication date: Available online 4 July 2019Source: Medical HypothesesAuthor(s): Gilles R.G. MonifAbstractUsing the gross pathology literature and the prior decoupling of Crohn's disease from inflammatory bowel disease, IDI's White Paper puts into question the current understanding of what ulcerative colitis is and how it can be therapeutically addressed. The pathology literature, when coupled with the ability of fecal...
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JoVE: Journal of Visualized ExperimentsA Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound HealingClosure of catastrophic open abdominal wounds presents a challenge to the surgeon. We present a surgical technique utilizing a combination of mechanical and biologic xenograft closure systems in closing complex open abdominal wounds. This technique offers another option to the surgeon for definitive...
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Open Forum Infectious Diseases - current issue,Retrospective Study Demonstrating High Rates of Sustained Virologic Response After Treatment With Direct-Acting Antivirals Among American Indian/Alaskan NativesAbstractBackgroundTreatment for chronic hepatitis C virus (HCV) has rapidly evolved to simple, well-tolerated, all-oral regimens of direct-acting antivirals (DAAs). There are few data on the epidemiology of HCV in American Indians/Alaska Natives (AI/ANs), a population disproportionately affected...
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Academic Radiology,Ultrasound-guided Therapeutic Injection and Cryoablation of the Medial Plantar Proper Digital Nerve (Joplin's Nerve): Sonographic Findings, Technique, and Clinical OutcomesPublication date: Available online 3 July 2019Source: Academic RadiologyAuthor(s): Christopher J. Burke, Julien Sanchez, William R. Walter, Luis Beltran, Ronald AdlerRationale and ObjectivesThe medial plantar proper digital nerve, also called Joplin's nerve, arises from the medial plantar nerve, courses along...
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Audiology,Researchers Create First Complete Virtual Eodel of the Ear's Speech SensorResearchers from the University of Michigan have discovered how to represent the part of the ear that processes speech in a computer model. This creation can help improve hearing tests and devices that restore some hearing to the deaf. The cochlea takes pressure information from the eardrum and turns it into nerve impulses that are then sent to the brain. A full understanding of how that tube-like structure works,...
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Genes,Single-nucleotide polymorphisms (rs342275, rs342293, rs7694379, rs11789898, and rs17824620) showed significant association with lobaplatin-induced thrombocytopeniaPublication date: Available online 4 July 2019Source: GeneAuthor(s): Panpan Lv, Shaoxing Yang, Fangfang Wu, Wenjing Liu, Haifeng Qin, Xiuhua Tang, Zeyuan Liu, Hongjun GaoAbstractThis study aimed to investigate single-nucleotide polymorphisms (SNPs) associated with lobaplatin-induced thrombocytopenia in patients with advanced lung...
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Benign thyroid nodules in pediatric patients: determining best practices for repeat ultrasound evaluationsJuanita K. Hodax / Kimberly Bowerman / Jose Bernardo QuintosPublished Online: 2019-07-04 | DOI: https://doi.org/10.1515/jpem-2018-047630,00 € / $42.00 / £23.00 GET ACCESS TO FULL TEXTAbstractObjectiveThe American Thyroid Association (ATA) recommendations for the follow-up of thyroid nodules with benign fine needle aspiration (FNA) cytology in children are largely based on adult data, despite...
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Sibel Kocaaslan Atli / Nihal Olgaç Dündar / Onur Bayazit / Nur Evirgen Esin / Uğraş Erdoğan / Gönül Çatli / Mehmet Cemal Kahya / Bumin Nuri DündarPublished Online: 2019-06-11 | DOI: https://doi.org/10.1515/jpem-2018-046330,00 € / $42.00 / £23.00 GET ACCESS TO FULL TEXTAbstractBackgroundThe aim of this study was to examine the cognitive functions of children with subclinical hypothyroidism (SH) and healthy children with the use of auditory event-related potentials (AERPs) and neuropsychological tests.MethodsTwenty...
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Clinical Endocrinology,Changes in whole metabolites after exenatide treatment in overweight/obese polycystic ovary syndrome patientsSummary Objective Exenatide is a new agent for diabetes therapy, and its use in polycystic ovary syndrome (PCOS) has gradually increased; however, the clinical benefit and metabolic improvement need further evidence. This research aimed to study the changes in whole metabolites before and after exenatide treatment in overweight/obese PCOS patients to gain a better understanding...
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Mortality and health-related quality of life following injuries and associated factors:a cohort study in Chandigarh, North India Thu Jul 04, 2019 19:00by Jagnoor, J., Prinja, S., Nguyen, H., Gabbe, B. J., Peden, M., Ivers, R. Q. via Online FirstIntroductionInjuries are among the 10 leading causes of deaths worldwide. In recent years, the quality and reporting of injury mortality has improved but little or no data are available on the morbidity burden and impact of non-fatal injuries in India. This...
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The Journal of Dermatology,Extracellular signal‐regulated kinase activation of self‐healing Langerhans cell histiocytosis: A case reportAbstract A 3‐month‐old boy developed small papules on his trunk. After the papules increased in number, the patient was diagnosed with Langerhans cell histiocytosis based on the pathological findings. He was referred to our department for further examination. Upon initial examination, the papules and nodules were scattered on his back, abdomen and lumbar region....
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Contemporary Clinical Trials,Improving family caregiver and patient outcomes in lung cancer surgery: Study protocol for a randomized trial of the multimedia self-management (MSM) interventionPublication date: Available online 3 July 2019Source: Contemporary Clinical TrialsAuthor(s): Virginia Sun, Dan J. Raz, Loretta Erhunmwunsee, Nora Ruel, Jacqueline Carranza, Rosemary Prieto, Betty Ferrell, Robert S. Krouse, Ruth McCorkle, Jae Y. KimAbstractObjectiveTo describe the study protocol of the Multimedia...
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Blood CLINICAL TRIALS AND OBSERVATIONS,Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genesEvans syndrome (ES) is a rare severe autoimmune disorder characterized by the combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most cases, the underlying cause is unknown. We sought to identify genetic defects in pediatric ES (pES), based on a hypothesis of strong genetic determinism. In a national, prospective cohort of 203...
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Pigment Cell & Melanoma Research,Discoidin Domain Receptors: A promising target in melanomaAbstract The Discoidin Domain Receptor 1 (DDR1) is a member of the receptor tyrosine kinase family that signals in response to collagen and that has been implicated in cancer progression. In the present study, we investigated the expression and role of DDR1 in human melanoma progression. Immunohistochemical staining of human melanoma specimens (n = 52) shows high DDR1 expression in melanoma lesions that...
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Cell Research - AOP,Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinomaCell Research, Published online: 04 July 2019; doi:10.1038/s41422-019-0195-ySingle-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinomaCell Research - AOPThu Jul 04, 2019 03:00Mark above section as read CellsCells, Vol. 8, Pages 679: Ameliorating the Fibrotic Remodeling of the Heart through Direct...
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European Journal of Surgical Oncology (EJSO),Surgical treatment of vulvar cancer: Impact of tumor-free margin distance on recurrence and survival. A multicentre cohort analysis from the francogyn study groupPublication date: Available online 3 July 2019Source: European Journal of Surgical OncologyAuthor(s): E. Raimond, C. Delorme, L. Ouldamer, X. Carcopino, S. Bendifallah, C. Touboul, E. Daraï, M. Ballester, O. Graesslin, For the Research group FRANCOGYNAbstractObjectiveIn vulvar cancer, it is admitted...
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Cancer/Radiothérapie,« Proposition de délinéation des volumes cibles tumoraux et sélection des aires ganglionnaires des cancers de la glande parotide » report [Cancer Radiother. 23 (2019) 255–263]Publication date: Available online 3 July 2019Source: Cancer/RadiothérapieAuthor(s): L. Piram, T. Frédéric-Moreau, R. Bellini, F. Martin, J. Miroir, N. Saroul, N. Pham Dang, J. Biau, M. LapeyreScienceDirect Publication: Cancer/RadiothérapieThu Jul 04, 2019 17:12
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The pretreatment erythrocyte sedimentation rate predicts survival outcomes after surgery and adjuvant radiotherapy for extremity soft tissue sarcoma,Thu Jul 04, 2019 03:00by Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung via Radiation Oncology - Latest ArticlesSystemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative...
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Primary adenoid cystic carcinoma of the trachea: clinical outcome of 38 patients after interdisciplinary treatment in a single institution,Thu Jul 04, 2019 03:00by Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl via Radiation Oncology - Latest ArticlesPrimary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting...
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Practical Radiation Oncology,On the other side of the deskPublication date: Available online 4 July 2019Source: Practical Radiation OncologyAuthor(s): Daniel E. RoosPractical Radiation OncologyThu Jul 04, 2019 19:58Practice patterns among radiation oncologists treating pediatric patients with proton craniospinal irradiationPublication date: Available online 4 July 2019Source: Practical Radiation OncologyAuthor(s): Sara Medek, Brian De, Luke Pater, John Breneman, Anita Mahajan, Suzanne Wolden, Ralph...
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Journal of Neuro-Oncology,Phase II study of weekly carboplatin in pretreated adult malignant gliomasAbstract Purpose Patients with relapse of recurrent glioma have a poor outcome and limited treatment options. The aim of this study is to investigate the clinical benefit and tolerability of weekly intravenous administration of carboplatin-based monotherapy in adult glioma patients who had progressed from previous chemotherapy lines based on temozolomide and nitrosoureas. Methods...Latest Results for...
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Journal of Cancer Survivorship,Preferences for cancer survivorship care among adolescents and young adults who experienced healthcare transitions and their parentsAbstract Purpose This study aimed to elucidate experiences and preferences for survivorship care delivery among adolescent and young adult (AYA) childhood cancer survivors who experienced healthcare transitions. Methods Eight focus groups were conducted with two groups of AYA survivors and their parents: (1) those who recently completed...
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Cancer Research and Clinical Oncology,Low number of intrafollicular T cells may predict favourable response to rituximab-based immuno-chemotherapy in advanced follicular lymphoma: a secondary analysis of a randomized clinical trialAbstract Background First-line rituximab therapy together with chemotherapy is the standard care for patients with advanced follicular B-cell lymphoma, as rituximab together with chemotherapy prolongs progression-free and overall survival (Herold et al. 2007; Marcus et...
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Journal of Experimental & Clinical Cancer Research - CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesisCDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.Journal of Experimental & Clinical Cancer Research - Latest ArticlesThu Jul 04, 2019 03:00ResearchOpen AccessCDK5-mediated phosphorylation and stabilization of...
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International Journal of Cancer,Small Molecular Modulators of JMJD1C Preferentially Inhibit Growth of Leukemia CellsHistone demethylases are promising therapeutic targets as they play fundamental roles for survival of Mixed lineage leukemia rearranged acute leukemia (MLLr AL). Here we focused on the catalytic Jumonji domain of histone H3 lysine 9 (H3K9) demethylase JMJD1C to screen for potential small molecular modulators from 149,519 natural products and 33,765 Chinese medicine components via virtual...
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Future Oncology,Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysisFuture Oncology, Ahead of Print.Future OncologyThu Jul 04, 2019 11:38FUTURE ONCOLOGYAHEAD OF PRINT SYSTEMATIC REVIEWComparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysisShao-wu Jing‡, Jian-jun Qin‡, Qing Liu, Chang Zhai, Ya-jing Wu, Yun-jie Cheng, Brian G Czito & Jun WangPublished Online:4 Jul 2019https://doi.org/10.2217/fon-2019-0024View...
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European Journal of Cancer,More rationale for optimal sequencing of therapeutic monoclonal antibodies in metastatic colorectal cancerPublication date: August 2019Source: European Journal of Cancer, Volume 117Author(s): Gerard MilanoEuropean Journal of CancerThu Jul 04, 2019 18:48Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' <em>i</em>LOC study by the Lymphoma study association...
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Clinical Lung Cancer,Predictors of respiratory decline following stereotactic ablative radiotherapy to multiple lung tumorsThe safety and efficacy of stereotactic ablative radiation therapy (SABR) to multiple lung tumors remains unclear. We retrospectively reviewed a total of 86 patients treated with SABR to 203 lung tumors. We observed excellent local control and low rates of conventional metrics of toxicity, but there was a high rate of respiratory decline after treatment that warrants further...
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Clinical Cancer Research ,Viral targeting of non-muscle invasive bladder cancer and priming of anti-tumour immunity following intravesical Coxsackievirus A21Purpose: The CANON (CAVATAK in NON-muscle invasive bladder cancer) study evaluated a novel ICAM-1-targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer. Experimental Design: Fifteen patients enrolled on this 'window of opportunity' phase 1 study, exposing primary bladder cancers to CAVATAK prior to surgery....
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Cancers, Vol. 11, Pages 944: Systematic Review and Meta-Analysis of Randomized, Controlled Trials...
Cancers, Vol. 11, Pages 944: Systematic Review and Meta-Analysis of Randomized, Controlled Trials on Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung CancerCancers, Vol. 11, Pages 944: Systematic Review and Meta-Analysis of Randomized, Controlled Trials on Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung Cancer Cancers doi: 10.3390/cancers11070944 Authors: Ilem D. Rosero Robinson Ramírez-Vélez Alejando Lucia Nicolas Martínez-Velilla...
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Cancer Research Online First Articles,Poly (ADP) ribose glycohydrolase can be effectively targeted in pancreatic cancerPatients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than one year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohydrolase (PARG) is a strong candidate target due to its dependence on the pro-oncogenic mRNA stability factor HuR (ELAVL1). Here,...
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British Medical Journal,Compulsory vaccination: case isolation is likely to be more effectiveDraeger mentions herd immunity while discussing compulsory vaccination.1 The concept of herd immunity arises from ordinary differential equation models, with the population at risk mixing randomly....British Medical JournalThu Jul 04, 2019 15:31"Hostile and demeaning" universal credit system worsens physical and mental health, study findsUniversal credit (UC)—the new benefits system which combines six separate...
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BMC Cancer - Latest Articles,Peer support for the maintenance of physical activity and health in cancer survivors: the PEER trial - a study protocol of a randomised controlled trialDespite an overwhelming body of evidence showing the benefits of physical activity (PA) and exercise for cancer survivors, few survivors meet the exercise oncology guidelines. Moreover, initiating, let alone m...BMC Cancer - Latest ArticlesWed Jul 03, 2019 03:00Adherence to quality breast cancer survivorship care in four...
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Health - Google News,Best supplements for the brain: Three vitamins and minerals to maintain cognitive function - ExpressBest supplements for the brain: Three vitamins and minerals to maintain cognitive function ExpressBEST SUPPLEMENTS for the brain: Doing everything you can to keep your brain healthy is extremely important as it's responsible for controlling how the body ...Health - Google NewsThu Jul 04, 2019 20:31Scientists Map out the Entire Neural Wiring of an Animal's Nervous System - Interesting...
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Journal of Magnetic Resonance Imaging,Theoretical description of modern 1H in Vivo magnetic resonance spectroscopic pulse sequencesThis article reviews the most commonly used modern sequences designed to confront the two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial localization and metabolic specificity. The purpose of this review article is to provide a deeper and clearer understanding of the underlying mechanisms by which all modern MRS sequences operate. A descriptive...
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Incidence and treatment protocol for maxillofacial fungal osteomyelitis: A 12 year studyThe aims were to retrospectively determine the incidence of fungal osteomyelitis and outcome of surgical protocol and complications. (Source: Journal of Oral and Maxillofacial Surgery)Journal of Oral and Maxillofacial SurgeryThu Jul 04, 2019 00:00Neutrophil-to-Lymphocyte Ratio and Carotid Artery Calcified Plaque in Older Male Patients With Severe Obstructive Sleep ApneaI have read with interest the article by...
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Iatropedia.gr,Κατάθλιψη και καλοκαίρι: Οι 3 βασικοί λόγοι για την έξαρση συμπτωμάτων αυτή την εποχήΜπορεί το καλοκαίρι να είναι εξ ορισμού μια καλή περίοδος του χρόνου για την ψυχολογία μας, αλλά αυτό δεν σημαίνει πως τα πάντα γύρω από το καλοκαίρι θυμίζουν... στίχους από χαρούμενο τραγούδι. The post Κατάθλιψη και καλοκαίρι: Οι 3 βασικοί λόγοι για την έξαρση συμπτωμάτων αυτή την εποχή appeared first on Iatropedia.Iatropedia.gr08:00ΩΚΚ: Πραγματοποιήθηκε η πρώτη επιτυχής αγγειοπλαστική σε πνευμονικές...
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The Cerebellum,Dynamic Expression and New Functions of Early B Cell Factor 2 in Cerebellar DevelopmentAbstract The collier/Olf1/EBF family genes encode helix-loop-helix transcription factors (TFs) highly conserved in evolution, initially characterized for their roles in the immune system and in various aspects of neural development. The Early B cell Factor 2 (Ebf2) gene plays an important role in the establishment of cerebellar cortical topography and in Purkinje cell (PC) subtype specification....
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BioMed Research International,Phenothiazinium Dyes Are Active against Trypanosoma cruzi In VitroChagas disease is a tropical illness caused by the protozoan Trypanosoma cruzi. The disease affects populations of the Americas and has been spread to other continents due to the migration process. The disease is partially controlled by two drugs, Benznidazole and Nifurtimox. These molecules are active in the acute phase of the infection but are usually ineffective during the symptomatic chronic phase....
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BMC Research Notes,Prevalence and associated factors of uncontrolled hypertension among hypertensive patients: a nation-wide survey in ThailandThe objectives of the research were to determine the prevalence and factors associated of uncontrolled blood pressure among Thai hypertensive patients in a nationwide survey.BMC Research NotesThu Jul 04, 2019 03:00Mark above section as read BMJ Case Reports Last 6 Issues,Acute psychosis in glycogen storage disease: a rare but severe complicationGlycogen storage...
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Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicineThu Jul 04, 2019 16:24via ScienceDirect Publication: Journal of ProteomicsPublication date: Available online 4 July 2019Source: Journal of ProteomicsAuthor(s): Fan Yang, Danya Wang, Yongjia Tong, Chenghu Qin, Liuting Yang, Fei Yu, Xin Huang, Shuang Liu, Zhijian Cao, Lin Guo, Wenxin Li, Yingliang Wu, Xiaolu...
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The interface reaction pattern in the skin: An integrated review of clinical and pathological featuresThu Jul 04, 2019 18:12via Human PathologyPublication date: Available online 3 July 2019Source: Human PathologyAuthor(s): Maria A. Deschaine, Julia S. LehmanSummaryNot uncommonly, pathologists encounter biopsies displaying inflammation at the dermoepidermal junction and confronted with its numerous diagnostic possibilities. As with other inflammatory dermatoses, the correct diagnosis relies on careful...
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Coronary Heart Disease and an Incidental Parathyroid CarcinomaThu Jul 04, 2019 16:05via Case Reports in PathologyA 71-year-old woman was admitted with angina pectoris. During hospitalization she developed a myocardial infarction (NSTEMI). Laboratory results revealed a mild elevated troponin and an elevated calcium level (3.35 mmol/l). Subsequently, there was a decreased phosphate (0.36 mmol/l [normal 0.81-1.62 mmol/l]) as well as 16-fold elevated serum level of parathyroid hormone (PTH, 1156 ng/l...
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A randomised controlled trial of the pectoral nerves ‐2 (PECS‐2) block for radical mastectomy Thu...
A randomised controlled trial of the pectoral nerves ‐2 (PECS‐2) block for radical mastectomyThu Jul 04, 2019 19:09by A. Al Ja'bari, M. Robertson, K. El‐Boghdadly, E. Albrecht via AnaesthesiaSummaryWe randomly allocated 50 women scheduled for radical mastectomy to pectoral nerves‐2 (PECS‐2) block (n = 25) or no block (n = 25), 20 and 22 of whom we analysed for the primary outcome of a cumulative 24‐h postoperative morphine dose. We gave intra‐operative sufentanil, magnesium, dexamethasone and droperidol....
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Annals of Allergy, Asthma & Immunology,Precision Medicine for Lung Diseases: A National Heart, Lung, and Blood Institute PerspectivePersonalized medicine is not new. For centuries physicians have provided individualized care based on the nuanced clinical presentations of patients and the severity of their diseases. However, analytical advances over the past decade have sparked a hope that we may soon be able to deliver medical care with unprecedented resolution and effectiveness. To distinguish...
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Allergy,Immediate versus delayed cow's milk protein allergy in terms of tolerance at year onePublication date: Available online 3 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Ioannis Xinias, Dimitrios Cassimos, Grigorios Trypsianis, Maria Nivatsi, Antigoni MavroudiAllergyThu Jul 04, 2019 17:01Weed Pollen Season Trends In Relation To Atmospheric Co<sub>2</sub> Changes In Indiana And OhioPublication date: Available online 3 July 2019Source: Annals of Allergy, Asthma...
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MedWorm Cancer & Oncology Research,A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-aminesA series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous colon adenocarcinoma (CT26)...
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MedWorm Cancer & Oncology Research,Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1DPurpose of review Although checkpoint inhibitor blockade is now widely used clinically for cancer immunotherapy, the reverse process, (i.e. induction of checkpoints to slow autoimmunity) has not been extensively explored. CD8 T-cell exhaustion is a state of immune hyporesponsiveness that may be harnessed to treat autoimmunity. Recent findings We focus on the potential role of CD8 T-cell...
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MedWorm ENT & OMF Research,Chain Formation of Laryngeal Granulomas on the Epiglottis After Iatrogenic Trauma.Authors: Oreški I, Gregurić T, Aras I, Mašić S, Stevanović S PMID: 31266400 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.MedWorm ENT & OMF...
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MedWorm ENT & OMF Research,Facial Transplantation: What does the future hold?Publication date: Available online 3 July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Joshua E. Lubek (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)MedWorm ENT & OMF Research05:36What Characteristics do Orthodontists Desire in Orthognathic Surgeons?ConclusionsOrthodontists' most desirable characteristic in an orthognathic surgeon is an understanding...
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Role of Pigment Epithelium-Derived Factor in Arsenic-Induced Vascular Endothelial Dysfunction in a Rat ModelAbstractWater-borne arsenicosis is caused by the consumption of excess levels of inorganic arsenic from drinking water and is a worldwide public health issue. Arsenic exposure has recently attracted extensive attention due to its damage to the cardiovascular system. Vascular endothelial dysfunction (VED) is recognized as an important cause of cardiovascular diseases. Pigment epithelium-derived...
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Mindfulness and Character Strengths,AbstractObjectivesNumerous studies have confirmed robust relationships between general well-being and mindfulness or character strengths, respectively, but few have examined associations between mindfulness and character strengths. Two studies were carried out to explore these relationships comprehensively in the framework of the Values in Action (VIA) classification of character strengths.MethodsIn study 1, participants (N = 1335) completed validated assessments...
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Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene ExpressionsAbstractThe effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabetic...
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Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene ExpressionsAbstractThe effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabetic...
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Are We Forgetting Sati? Memory and the Benefits of Mindfulness from a Non-Buddhist ViewpointItem Response Theory Analysis of the Five Facet Mindfulness Questionnaire and Its Short FormsAbstractObjectivesThe Five Facet Mindfulness Questionnaire (FFMQ) is a self-report measure of mindfulness with forms of several different lengths, including the FFMQ-39, FFMQ-24, and FFMQ-15. We use item response theory analysis to directly compare the functioning of these three forms.MethodsData were drawn from a...
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Depression and ADHD-Related Risk for Substance Use in Adolescence and Early Adulthood: Concurrent and Prospective Associations in the MTAAbstractChildhood attention-deficit/hyperactivity disorder (ADHD) is prospectively linked to substance use and disorder. Depression emerging in adolescence is an understudied risk factor that may explain some of this risk. In the present study, we considered mediating and moderating roles of adolescent depression in explaining this association by using longitudinal...
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A Dynamic Examination of the Associations between Shyness, Psychological Difficulties, and Stressful Life Events during Early AdolescenceAbstractAlthough numerous studies have established linkages between shyness and later psychological difficulties, most extant research did not examine variation in shyness over time in relation to variation in psychological difficulties over time or possible environmental factors of influence outside of the school context. The current study used multi-level modelling...
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Frontal Brain Asymmetry and the Trajectory of Shyness Across the Early School YearsAbstractAlthough resting right frontal electroencephalogram (EEG) asymmetry has been linked to avoidance and withdrawal-related behaviors such as shyness in previous cross-sectional studies, relatively little research has examined the influence of frontal brain electrical activity on the development of shyness in children using a prospective, longitudinal study design. Here, we tested whether resting frontal EEG asymmetry...
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Latest articlesSound Level Measurements in Berthing Areas of an Aircraft CarrierEmployment Quality: An Overlooked Determinant of Workers' Health and Well-being?Identification of the Minimum Number of Measurements Required for Thermal Comfort Assessment in Large WorkplacesGlobe Temperature and Its Measurement: Requirements and LimitationsShift Work and Leukocyte Count Changes among Workers in BangkokMost readExposure-Related Health Effects of Silver and Silver Compounds: A ReviewPredicting evaporation...
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The Use of Metabolomics to Identify Biological Signatures of Manganese Exposure.Baker MG1, Simpson CD1, Lin YS2, Shireman LM2, Seixas N1.Author information1Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE Suite 100, Seattle, WA 98105, USA.2Department of Pharmaceutics, University of Washington, H272 Health Science Building, Seattle WA 98195, USA.AbstractOBJECTIVES:Manganese (Mn) is a known neurotoxicant, and given its health effects and...
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Advance articles alert 30 June 2019 - 01 July 2019 Penicillin as a Potential Agent for Dual Beta-lactam Therapy for Enterococcal Endocarditis B J Tritle; T T Timbrook; M A Fisher; E S Spivak Sources of Airborne Norovirus in Hospital Outbreaks Malin Alsved; Carl-Johan Fraenkel; Mats Bohgard; Anders Widell ; Anna Söderlund-Strand ... Asymptomatic infection and transmission of pertussis in households: a systematic review Rodger Craig, MPH; Elizabeth Kunkel, MScPH; Natasha S Crowcroft, MD(Cantab); Meagan...
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The Association Between Bronchial Wall CT Attenuation and Spirometry in Patients with Bronchial AsthmaPublication date: July 2019Source: Academic Radiology, Volume 26, Issue 7Author(s): Shoichiro Matsushita, Tsuneo Yamashiro, Shin Matsuoka, Kunihiro Yagihashi, Yasuo NakajimaRationale and ObjectiveThe purpose of this study was to evaluate the correlation between generation-based bronchial wall attenuation on thin-section computed tomography (CT) scans and airflow limitation in patients with bronchial...
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Influence of Monoenergetic Images at Different Energy Levels in Dual-Energy Spectral CT on the Accuracy of Computer-Aided Detection for Pulmonary EmbolismPublication date: July 2019Source: Academic Radiology, Volume 26, Issue 7Author(s): Guangming Ma, Yuequn Dou, Shan Dang, Nan Yu, Yanbing Guo, Chuangbo Yang, Shuanhong Lu, Dong Han, Chenwang JinPurposeTo investigate the influence of monoenergetic images of different energy levels in spectral computed tomography (CT) on the accuracy of computer aided...
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Reliability of MRI-Derived Depth of Invasion of Oral Tongue CancerPublication date: July 2019Source: Academic Radiology, Volume 26, Issue 7Author(s): Ryuji Murakami, Shinya Shiraishi, Ryoji Yoshida, Junki Sakata, Keisuke Yamana, Akiyuki Hirosue, Yoshikazu Uchiyama, Hideki Nakayama, Yasuyuki YamashitaRationale and ObjectiveTo evaluate the inter-rater reliability of the magnetic resonance imaging (MRI)-derived depth of invasion (DOI) and the agreement between MRI and pathological measurements of oral...
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Ultrasound-guided Therapeutic Injection and Cryoablation of the Medial Plantar Proper Digital Nerve (Joplin's Nerve): Sonographic Findings, Technique, and Clinical OutcomesPublication date: Available online 3 July 2019Source: Academic RadiologyAuthor(s): Christopher J. Burke, Julien Sanchez, William R. Walter, Luis Beltran, Ronald AdlerRationale and ObjectivesThe medial plantar proper digital nerve, also called Joplin's nerve, arises from the medial plantar nerve, courses along the medial hallux...
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Inner Ear Drug Delivery: Tomorrow's Treatment for Hearing Loss?By Sueanne Phan, MBAThe growing need for hearing loss treatment has spurred the development of many inner ear therapies for indications from drug ototoxicity to inner ear disorders, but significant challenges need to be overcome to turn these options into reality. Read more. Malaria Drug Could Moderate Genetic Hearing LossBy Alexis GuerraThe antimalarial drug artemisinin can potentially restore inner ear sensory cell function and hearing...
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Relevant Topical Skin Care Products for Prevention and Treatment of Aging SkinOptions for skin care are varied. New products are introduced constantly and it is important for the practitioner to have an understanding of products that impart beneficial results for aging skin. Educating patients to use products with scientifically proven benefits leads to better outcomes. Patients should be encouraged to use daily sunscreen, a topical retinoid every night, and a topical antioxidant daily. Supplementing...
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Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA)Publication date: September 2019Source: Molecular and Cellular Neuroscience, Volume 99Author(s): Wen-Ning Zhao, Norma K. Hylton, Jennifer Wang, Peter S. Chindavong, Begum Alural, Iren Kurtser, Aravind Subramanian, Ralph Mazitschek, Roy H. Perlis, Stephen J. HaggartyAbstractA subset of individuals with major depressive disorder (MDD) elects treatment with complementary...
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