Image Processing in Biomedical Diagnosis

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[KRAS mutation does not influence oxaliplatin or irinotecan efficacy, in association with bevacizumab, in first line treatment of metastatic colorectal cancer].

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[KRAS mutation does not influence oxaliplatin or irinotecan efficacy, in association with bevacizumab, in first line treatment of metastatic colorectal cancer].

Bull Cancer. 2016 May 4;

Authors: Cabart M, Frénel JS, Campion L, Ramée JF, Dupuis O, Senellart H, Hiret S, Douillard JY, Bennouna J

Abstract
INTRODUCTION: The identification of RAS status (KRAS and NRAS) has changed the management of metastatic colorectal cancer (mCRC). The impact of the RAS mutation on cytotoxic chemotherapy efficacy has not yet been determined. Nevertheless, several retrospective studies suggest a greater efficacy of oxaliplatin in mCRC with KRAS mutation.
METHODS: We analyzed retrospectively the progression free survival (PFS) and overall survival (OS) in 216 patients with mCRC receiving first line treatment between 2008 and 2010 according to KRAS status and chemotherapy regimen used (oxaliplatin- or irinotecan-based, in association with fluoropyrimidine and bevacizumab).
RESULTS: In KRAS mutated tumors, median OS was 23.4 months with oxaliplatin-based regimen, and 23.6 months with irinotecan-based regimen, with no significant difference (HR 1.30; 95 % CI 0.81-2.09; P=0.27). In KRAS wild-type tumors, median OS was 30.3 months with oxaliplatin-based regimen, and 25.4 months with irinotecan-based regimen, with no significant difference (HR 0.81; 95 % CI 0.52-1.24; P=0.33). Similarly, KRAS mutational status had no significant effect on efficacy of oxaliplatin or irinotecan regarding PFS.
DISCUSSION: In this retrospective study, KRAS mutational status does not influence the efficacy of first line cytotoxic chemotherapy in association with bevacizumab.

PMID: 27155924 [PubMed - as supplied by publisher]

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Prevalence of leprous neuropathy determined by neurosensory testing in an endemic zone in Ecuador: Development of an algorithm to identify patients benefiting from early neurolysis.

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Prevalence of leprous neuropathy determined by neurosensory testing in an endemic zone in Ecuador: Development of an algorithm to identify patients benefiting from early neurolysis.

J Plast Reconstr Aesthet Surg. 2016 Apr 7;

Authors: Baltodano PA, Rochlin DH, Noboa J, Sarhane KA, Rosson GD, Dellon AL

Abstract
The success of a microneurosurgical intervention in leprous neuropathy (LN) depends on the diagnosis of chronic compression before irreversible paralysis and digital loss occurs. In order to determine the effectiveness of a different approach for early identification of LN, neurosensory testing with the Pressure-Specified Sensory Device™ (PSSD), a validated and sensitive test, was performed in an endemic zone for leprosy. A cross-sectional study was conducted to analyze a patient sample meeting the World Health Organization (WHO) criteria for Hansen's disease. The prevalence of LN was based on the presence of ≥1 abnormal PSSD pressure threshold for a two-point static touch. A total of 312 upper and lower extremity nerves were evaluated in 39 patients. The PSSD found a 97.4% prevalence of LN. Tinel's sign was identified in 60% of these patients. An algorithm for early identification of patients with LN was proposed using PSSD testing based on the unilateral screening of the ulnar and deep peroneal nerves.

PMID: 27156203 [PubMed - as supplied by publisher]

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German emigré psychologists in Tel Aviv (1934-1958): Max M. Stern and Margarete Braband-Isaac in conflict with Erich Neumann

Liebscher, M; (2016) German emigré psychologists in Tel Aviv (1934-1958): Max M. Stern and Margarete Braband-Isaac in conflict with Erich Neumann. History of the Human Sciences (In press). Green open access

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Computational studies of heavy element complexes.

O'Grady, E.M.; (2005) Computational studies of heavy element complexes. Doctoral thesis, University of London. Green open access

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Automated design of separation processes using implicit enumeration and interval analysis.

O'Grady, A.R.F.; (2005) Automated design of separation processes using implicit enumeration and interval analysis. Doctoral thesis, University of London. Green open access

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Lipidic peptide dendrimers: Potential gene delivery agents for the treatment of haemophilia B.

O'Donnell, M.W.; (2005) Lipidic peptide dendrimers: Potential gene delivery agents for the treatment of haemophilia B. Doctoral thesis, University of London. Green open access

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