Αρχειοθήκη ιστολογίου

Πέμπτη 2 Ιουνίου 2016

Immune checkpoint blockade in ovarian cancer

Summary

Increased numbers of tumour infiltrating T‑cells have long been associated with a better prognosis in ovarian cancer, which has led to the general assumption of a relevant impact of T‑cellular anti-tumour immunity in this disease. As a consequence of this knowledge, a multitude of immunologic therapies has emerged over the past years. Although some reports could evidence a successful induction of anti-tumour T‑cells, in general, these attempts did not translate into clinically significant activity. As has already been shown in other tumour entities, immune checkpoint blockade – mainly antibodies directed against PD-1 and PD-L1 – could possibly become a real "game changer" in ovarian cancer in the future.



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Multiple cytokine-producing primary cutaneous anaplastic large cell lymphoma



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Abdominal aortic thrombosis secondary to reactive thrombocytosis in a patient with iron deficiency anemia



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Frequency of silent cerebral ischemia in patients with transfusion-dependent β-thalassemia major compared to healthy individuals



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Editorial Board

Publication date: June 2016
Source:Gait & Posture, Volume 47





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Contents List

Publication date: June 2016
Source:Gait & Posture, Volume 47





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Agreement of the activPAL3 and activPAL for characterising posture and stepping in adults and children

Publication date: Available online 1 June 2016
Source:Gait & Posture
Author(s): Ceri Sellers, Philippa Dall, Margaret Grant, Ben Stansfield
Characterisation of physical activity and sedentary behaviour under free-living conditions is becoming increasingly important in light of growing evidence for the health implications of these behaviours. The integrity of long-term follow-up and the ability to compare outcomes between studies is critically dependent on the agreement of outcomes from successive generations of monitors. This study evaluated the agreement of the activPAL and second generation activPAL3 devices. Agreement was assessed in both adults (median 27.6y IQR 22.6) (n=20) and young people (median 12.0y IQR 4.1) (n=8) during standardised and daily living (ADL) test activities. During standardised activities; sedentary duration, upright duration, stepping duration and overall number of steps were all detected within small limits of agreement (≤5%). However, the activPAL characterised more steps during jogging than the activPAL3 (adults +8.36%, young people +6.80%). Also during ADL differences arose due to different posture characterisation in young people and lower step detection in the activPAL than the activPAL3 (adults −20.58%, young people −11.43%). Second-by-second posture analysis demonstrated high levels (>90%) of agreement for all activities between monitors. However, sensitivity (68.7%) and positive predictive value (78.8%) for adult stepping demonstrated disagreement between monitor interpretation of movement patterns during ADL. Agreement between monitor outcomes for standardised activities provides confidence that these outcomes can be considered almost equivalent. However, for characterisation of jogging and smaller movements during ADL it is likely that significant differences between monitor outcomes will arise.



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