Issue Information

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Corrigendum

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Clinical Snippets

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Review of the implementation of plasma ctDNA testing on behalf of IQN Path ASBL: a perspective from an EQA providers’ survey

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Use and Perceptions of Electronic Cigarettes Among Caregivers of Infants and Children with Bronchopulmonary Dysplasia

Pediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0.


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Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells

Publication date: Available online 24 August 2017
Source:Auris Nasus Larynx
Author(s): Kwang-Jae Cho, Eun-Ji Park, Min-Sik Kim, Young-Hoon Joo
ObjectivesThe aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC.MethodsA radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated.ResultsFaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44^high/ALDH^high FaDu-R cells demonstrated significantly faster wound closure (p<0.05) and more efficient invasion (p<0.05) compared to the CD44^high/ALDH^high FaDu cells or the CD44^low/ALDH^low FaDu-R cells. There was a significant difference in tumor volume between the CD44^high/ALDH^high FaDu-R cells and the CD44^high/ALDH^high FaDu cells (p<0.05) as well as the CD44^low/ALDH^low FaDu-R cells (p<0.05).ConclusionCancer stem cells (CSC) were associated with invasion and tumorigenesis in a radioresistant head and neck squamous cell carcinoma (HNSCC) cell line. This concept might help to improve the understanding of these mechanisms and to develop drugs that can overcome radioresistance during radiotherapy.



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Risk factors for the occurrence of epistaxis: Prospective study

Publication date: Available online 24 August 2017
Source:Auris Nasus Larynx
Author(s): Filipa Camacho Côrte, Tiago Orfao, Cláudia Camila Dias, Carla Pinto Moura, Margarida Santos
ObjectiveAnalyse and compare the characteristics of patients with epistaxis admitted to the otolaryngology emergency department with those provided by a control group. Establish a model to identify epistaxis predictive factors.MethodsProspective analysis of 283 consecutive adults, admitted to the otolaryngology emergency department of a tertiary referral centre between 25 January and 25 February 2014. Comparison of gender, age, co-morbidities, usual medication, history of epistaxis or nasal trauma, presence of septal deviation and blood pressure value on admission, between the elements that were admitted to the emergency due to epistaxis (group 1) and a group composed of patients with other symptoms (group 2). Intergroup variations were analyzed using t student and chi-square tests. Multivariate logistic regression and a receiver operating characteristic curve were used to establish a predictive model and test its suitability.ResultsMale gender (OR=2.57, 95% CI 1.1–6.0, p=0.029), older age (OR=1.03, 95% CI 1.0–1.1, p=0.002), existence of peripheral vascular disease (OR=13.47, 95% CI 1.9–95.3, p=0.009), cardiovascular disease (OR=3.91, 95% CI 1.6–9.7, p=0.003) and previous history of epistaxis (OR=5.53, 95% CI 2.5–12.1, p<0.001) were predictors of epistaxis when adjusted for the presence of elevated blood pressure, history of hypertension, cerebrovascular disease and chronic use of anticoagulants or antiplatelet drugs. The model revealed a good applicability (area under the curve of 0.852).ConclusionsThe only predictive factors of admission to the emergency department due to epistaxis were male gender, older age, peripheral vascular disease, cardiovascular disease and history of epistaxis.



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