Bimatoprost ophthalmic solution in facial vitiligo

Summary

Background

Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes.

Aim

To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo.

Material and methods

Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic solution once daily for 12 weeks. Photographic records were taken at 2 weeks follow-up along with dermoscopic (Polarized, 10×) evaluation.

Results

Four cases had excellent repigmentation, two cases had partial repigmentation and two cases had poor response.

Conclusion

Bimatoprost seems to be promising in treating stable vitiligo but large-scale studies are required.

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Post operative palatal cleft with synechia of tonsillar pillar and uvula – Could vascular ischemia be the etiology?

Publication date: Available online 6 October 2017
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Author(s): Surendra B. Patil, Shree Harsh
Post operative cleft of palate is a known complication of palatal split surgery. We present a post operative case of nasopharyngeal angiofibroma who presented with nasal twang in voice. Examination revealed cleft of soft palate with fusion of left side of uvula with the left tonsillar pillar. He underwent reconstruction of the left tonsillar pillar, left side of uvula and pushback palatoplasty. The aim of this article is to bring this unusual complication of palatal split surgery and it's management.



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Unilateral Nasal Obstruction.

Unilateral Nasal Obstruction.

JAMA Otolaryngol Head Neck Surg. 2017 Oct 05;:

Authors: Mikals SJ, McCuiston AM, Ramanathan M

PMID: 28983574 [PubMed - as supplied by publisher]

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Viral Diagnostics

Viral Immunology , Vol. 0, No. 0.


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A Possible Association Between Hearing Loss and Zika Virus Infections.

A Possible Association Between Hearing Loss and Zika Virus Infections.

JAMA Otolaryngol Head Neck Surg. 2017 Oct 05;:

Authors: Mittal R, Fifer RC, Liu XZ

PMID: 28983567 [PubMed - as supplied by publisher]

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Zika Virus: Immune Evasion Mechanisms, Currently Available Therapeutic Regimens, and Vaccines

Viral Immunology , Vol. 0, No. 0.


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Measuring Institutional Quality in Head and Neck Surgery Using Hospital-Level Data: Negative Margin Rates and Neck Dissection Yield.

Measuring Institutional Quality in Head and Neck Surgery Using Hospital-Level Data: Negative Margin Rates and Neck Dissection Yield.

JAMA Otolaryngol Head Neck Surg. 2017 Oct 05;:

Authors: Schoppy DW, Rhoads KF, Ma Y, Chen MM, Nussenbaum B, Orosco RK, Rosenthal EL, Divi V

Abstract
Importance: Negative margins and lymph node yields (LNY) of 18 or more from neck dissections in patients with head and neck squamous cell carcinomas (HNSCC) have been associated with improved patient survival. It is unclear whether these metrics can be used to identify hospitals with improved outcomes.
Objective: To determine whether 2 patient-level metrics would predict outcomes at the hospital level.
Design, Setting, and Participants: A retrospective review of records from the National Cancer Database (NCDB) was used to identify patients who underwent primary surgery and concurrent neck dissection for HNSCC between 2004 and 2013. The percentage of patients at each hospital with negative margins on primary resection and an LNY 18 or more from a neck dissection was quantified. Cox proportional hazard models were used to define the association between hospital performance on these metrics and overall survival.
Main Outcomes and Measures: Margin status and lymph node yield at hospital level. Overall survival (OS).
Results: We identified 1008 hospitals in the NCDB where 64 738 patients met inclusion criteria. Of the 64 738 participants, 45 170 (69.8%) were men and 19 568 (30.2%) were women. The mean SD age of included patients was 60.5 (12.0) years. Patients treated at hospitals attaining the combined metric of a 90% or higher negative margin rate and 80% or more of cases with LNYs of 18 or more experienced a significant reduction in mortality (hazard ratio [HR] 0.93; 95% CI, 0.89-0.98). This benefit in survival was independent of the patient-level improvement associated with negative margins (HR, 0.73; 95% CI, 0.71-0.76) and LNY of 18 or more (HR, 0.85; 95% CI, 0.83-0.88). Including these metrics in the model neutralized the association of traditional measures of hospital quality (volume and teaching status).
Conclusions and Relevance: Treatment at hospitals that attain a high rate of negative margins and LNY of 18 or more is associated with improved survival in patients undergoing surgery for HNSCC. These surgical outcome measures predicted outcomes independent of traditional, but generally nonmodifiable characteristics. Tracking of these metrics may help identify high-quality centers and provide guidance for institution-level quality improvement.

PMID: 28983555 [PubMed - as supplied by publisher]

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