Initiation of methotrexate with or without a test dose: a retrospective toxicity study

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Guselkumab in the Treatment of Hidradenitis Suppurativa: A Retrospective Chart Review

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Flush technique to minimize adverse reactions from syringe lubricant (silicone oil)

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British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018

Abstract

The overall objective of the guideline is to provide up‐to‐date, evidence‐based recommendations for the management of hidradenitis suppurativa (HS). The document aims to:.

offer an appraisal of all relevant literature up to July 2018, focusing on any key developments.

address important, practical clinical questions relating to the primary guideline objective.

provide guideline recommendations and if appropriate research recommendations.

This article is protected by copyright. All rights reserved.

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Effect of radiotherapy on the chemical composition of root dentin

Abstract

Background

The radiotherapy can directly affect the bond strength of the adhesive materials, interfering in the prognosis of restorative treatments, which may be caused by chemical changes in dentin structure.

Methods

Twenty inferior homologues premolars were distributed in 2 groups (in vitro study) (n = 10): nonirradiated and irradiated. The specimens were submitted to the analysis of phosphate (ν₁PO₄³⁻;ν₂PO₄³⁻;ν₄PO₄³⁻), carbonate (ν₃CO₃²⁻), amide I, CH₂, amide III, and amide I/III ratio by confocal Raman spectroscopy. Data were submitted to statistical analysis (T test, P < .05).

Results

In intracanal dentin, the irradiated group had lower ν₄PO₄³⁻ values (1.23 ± 0.06) compared to nonirradiated group (1.40 ± 0.18) (P < .05), with no difference for ν₁PO₄³⁻ and ν₂PO₄³ peaks (P > .05). The irradiated (1.56 ± 0.06) had lower carbonate, amide III (1.05 ± 0.19), and amide I/III ratio values (0.19 ± 0.06) compared to nonirradiated group (1.42 ± 0.10, 1.28 ± 0.24, and 0.31 ± 0.10, respectively) (P < .05). For medium dentin irradiated group (1.30 ± 0.12) had lower phosphate values compared to nonirradiated group (1.48 ± 0.22) (P < .05). In cementum, there was no statistical difference between the groups.

Conclusion

The radiotherapy was able to cause changes in ν₄PO₄³⁻, carbonate, and amide III peaks of root dentin.

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Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease

Abstract

Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. In this article, we provide a comprehensive review of recent breakthroughs, preliminary results of novel therapy, and future directions on the treatment of these complex malignancies.

https://ift.tt/2S1K7J9

Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity‐modulated radiation therapy

Abstract

Background

Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.

Methods

p16/epidermal growth factor receptor (EGFR)/cluster of differentiation‐44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.

Results

In the entire group and the p16 negative cohort, better 3‐year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16−, EGFR+/p16−, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup.

Conclusion

Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.

https://ift.tt/2A29bJ2