Perimarginal lymph nodes: an undervalued entity in oral cancer

Abstract

Purpose

In a previous study, we gave a surgical description of a group of lymph nodes in the submandibular area at risk of remaining undissected during neck dissection (ND) for which we have proposed the term "perimarginal nodes" (PMNs) due to their proximity to marginal mandibular nerve (MMN). The aim of this study is to evaluate prevalence of PMNs involvement in oral cavity squamous cell cancer (OCSCC) and to verify if metastases are related to primary tumor characteristics or to the state of the neck.

Methods

We recruited a total of 39 consecutive patients diagnosed with OCSCC candidate to ND. Histological characteristics of PMNs were analyzed and the incidence of metastases in relation to the primary tumor characteristics were noted.

Results

PMNs were found to be involved with metastases in 8 patients (20.5%). No characteristic of the primary tumor seems to influence the metastatic involvement of the PMNs.

Conclusions

PMNs represent a frequent site of micro-metastases in patients diagnosed with OCSCC regardless of other characteristics of the primary tumor.

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Correlated long-range mixed-harmonic fluctuations measured in pp, p+Pb and low-multiplicity Pb+Pb collisions with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Araujo Pereira, R; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aparisi Pozo, JA; Aperio Bella, L; Arabidze, G; Araque, JP; Araujo Ferraz, V; Araujo Pereira, R; - view fewer (2019) Correlated long-range mixed-harmonic fluctuations measured in pp, p+Pb and low-multiplicity Pb+Pb collisions with the ATLAS detector. Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics , 789 pp. 444-471. 10.1016/j.physletb.2018.11.065 . Green open access

http://bit.ly/2FI9RqK

Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses

Muir, L; McKay, PF; Petrova, VN; Klymenko, OV; Kratochvil, S; Pinder, CL; Kellam, P; Muir, L; McKay, PF; Petrova, VN; Klymenko, OV; Kratochvil, S; Pinder, CL; Kellam, P; Shattock, RJ; - view fewer (2018) Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses. Wellcome Open Research , 2 , Article 97. 10.12688/wellcomeopenres.11386.2 . Green open access

http://bit.ly/2FJMwoO

Segmenting accelerometer data from daily life with unsupervised machine learning

van Kuppevelt, D; Heywood, J; Hamer, M; Sabia, S; Fitzsimons, E; van Hees, V; (2019) Segmenting accelerometer data from daily life with unsupervised machine learning. PLoS One , 14 (1) , Article e0208692. 10.1371/journal.pone.0208692 . Green open access

http://bit.ly/2Fw0L1b

Exploration and Development of a C–H-Activated Route to Access the [1,2]Dithiolo[4,3-b]indole-3(4H)-thione Core and Related Derivatives

Hilton, ST; (2019) Exploration and Development of a C–H-Activated Route to Access the [1,2]Dithiolo[4,3-b]indole-3(4H)-thione Core and Related Derivatives. [Letter]. Synlett 10.1055/s-0037-1611692 . (In press).

http://bit.ly/2FG8nNG

Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

Wedderburn, LR; Webb, K; Peckham, H; Radziszewska, A; Menon, M; Oliveri, P; Simpson, F; ... Ioannou, Y; + view all Wedderburn, LR; Webb, K; Peckham, H; Radziszewska, A; Menon, M; Oliveri, P; Simpson, F; Deakin, CT; Lee, S; Ciurtin, C; Butler, G; Ioannou, Y; - view fewer (2019) Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration. Frontiers in Immunology , 9 , Article 3167. 10.3389/fimmu.2018.03167 . Green open access

http://bit.ly/2FzwCOb

Dark Energy Survey year 1 results: galaxy sample for BAO measurement

Crocce, M; Ross, AJ; Sevilla-Noarbe, I; Gaztanaga, E; Elvin-Poole, J; Avila, S; Alarcon, A; ... Zhang, Y; + view all Crocce, M; Ross, AJ; Sevilla-Noarbe, I; Gaztanaga, E; Elvin-Poole, J; Avila, S; Alarcon, A; Chan, KC; Banik, N; Carretero, J; Sanchez, E; Hartley, WG; Sanchez, C; Giannantonio, T; Rosenfeld, R; Salvador, AI; Garcia-Fernandez, M; Garcia-Bellido, J; Abbott, TMC; Abdalla, FB; Allam, S; Annis, J; Bechtol, K; Benoit-Levy, A; Bernstein, GM; Bernstein, RA; Bertin, E; Brooks, D; Buckley-Geer, E; Carnero Rosell, A; Kind, MC; Castander, FJ; Cawthon, R; Cunha, CE; D'Andrea, CB; da Costa, LN; Davis, C; De Vicente, J; Desai, S; Diehl, HT; Doel, P; Drlica-Wagner, A; Eifler, TF; Fosalba, P; Frieman, J; Garcia-Bellido, J; Gerdes, DW; Gruen, D; Gruendl, RA; Gschwend, J; Gutierrez, G; Hollowood, D; Honscheid, K; Jain, B; James, DJ; Krause, E; Kuehn, K; Kuhlmann, S; Kuropatkin, N; Lahav, O; Lima, M; Maia, MAG; Marshall, JL; Martini, P; Menanteau, F; Miller, CJ; Miquel, R; Nichol, RC; Percival, WJ; Plazas, AA; Sako, M; Scarpine, V; Schindler, R; Scolnic, D; Sheldon, E; Smith, M; Smith, RC; Soares-Santos, M; Sobreira, F; Suchyta, E; Swanson, MEC; Tarle, G; Thomas, D; Tucker, DL; Vikram, V; Walker, AR; Yanny, B; Zhang, Y; - view fewer (2019) Dark Energy Survey year 1 results: galaxy sample for BAO measurement. Monthly Notices of the Royal Astronomical Society , 482 (2) pp. 2807-2822. 10.1093/mnras/sty2522 . Green open access

http://bit.ly/2FyYySm