Behavioral characterization of CD36 knockout mice with SHIRPA primary screen

Publication date: 15 February 2016
Source:Behavioural Brain Research, Volume 299
Author(s): Shuxiao Zhang, Wei Wang, Juan Li, Ke Cheng, Jingjing Zhou, Dan Zhu, Deyu Yang, Zihong Liang, Liang Fang, Li Liao, Peng Xie
CD36 is a member of the class B scavenger receptor family of cell surface proteins, which plays a major role in fatty acid, glucose and lipid metabolism. Besides, CD36 functions as a microglial surface receptor for amyloid beta peptide. Regarding this, we suggest CD36 might also contribute to neuropsychiatric disease. The aim of this study was to achieve a behavioral phenotype of CD36 knockout (CD36^−/−) mice. We characterized the behavior of CD36^−/− mice and C57BL/6J mice by subjecting them to a series of tests, which include SHIRPA primary behavioral screen test, 1% sucrose preference test, elevated plus-maze test, open-field test and forced swimming test. The results showed that CD36^−/− mice traversed more squares, emitted more defecation, exhibited higher tail elevation and had more aggressive behaviors than C57BL/6J mice. The CD36^−/− mice spent more time and traveled longer distance in periphery zone in the open-field test. Meanwhile, the numbers that CD36^−/− mice entered in the open arms of elevated plus-maze were reduced. These findings suggest that CD36^−/− mice present an anxious phenotype and might be involved in neuropsychiatric disorders.



from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1XARjfG
via IFTTT