Publication date: Available online 25 July 2016
Source:Clinical Immunology
Author(s): Robert Winchester, Jon Giles, Deepak Jadon, Mohammed Haroon, Neill McHugh, Oliver FitzGerald
We sought to validate and extend the findings of a 282 psoriatic arthritis patient cohort from Dublin using a 219 patient cohort from Bath. The central finding of this study was that several structurally unrelated HLA alleles, including B*08:01:01, B*18:01:01, B*27:05:02, B*55:01:01 and C*06:02:01, were found to be significantly associated with particular phenotypic features of psoriatic arthritis, implying that the clinical diagnosis of psoriatic arthritis designates a genetically heterogeneous subset of individuals. Radiographic sacroiliitis was associated with either B*08:01:01, or B*27:05:02 with implications about the role of MHC molecules in an adaptive immune response. There are implications for psoriatic arthritis diagnostic criteria since some disease features used in the criteria are under genetic control. These findings have important implications for understanding the role of MHC alleles in directing the adaptive immune response to mediate the inflammation responsible for psoriatic arthritis.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2a1MyFr
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
-
▼
Ιουλίου
(1200)
-
▼
Ιουλ 26
(50)
- Learning a New Selection Rule in Visual and Fronta...
- Context-Dependent Duration Signals in the Primate ...
- Effects of Hypocretin/Orexin and Major Transmitter...
- Regulation of Cortical Dynamic Range by Background...
- Timing of Cortico-Muscle Transmission During Activ...
- Cortical Gray and Adjacent White Matter Demonstrat...
- Cortical Dependence of Whisker Responses in Poster...
- Default Mode Network Activity Predicts Early Memor...
- Mapping the Dynamic Network Interactions Underpinn...
- Decoding Concrete and Abstract Action Representati...
- Presynaptic Spike Timing-Dependent Long-Term Depre...
- Visual and Haptic Shape Processing in the Human Br...
- Motor Training Promotes Both Synaptic and Intrinsi...
- Resting-State Functional Connectivity of the Locus...
- Longitudinal Evidence for Smaller Hippocampus Volu...
- Accessing Real-Life Episodic Information from Minu...
- Frequency of Maternal Touch Predicts Resting Activ...
- The Suppression of Beta Oscillations in the Primat...
- Similarity-Based Fusion of MEG and fMRI Reveals Sp...
- Insights on methotrexate in psoriatic disease
- Implications of the diversity of class I HLA assoc...
- Direct versus sequential immunoglobulin switch in ...
- Autoimmunity against laminins
- Recent Advances in the Synthesis of Flavaglines, a...
- Synthesis of α-Acyloxynitrones and Reactivity towa...
- Expeditious Synthesis of Isoquinolones and Isocoum...
- Borosilicate Activation of (Difluoroiodo)toluene i...
- Cryptochirality in 2,2′-Coupled BODIPY DYEmers
- Correction: Beyond "turn-on" readout: from zero ba...
- Biobased Polyamides: Recent Advances in Basic and ...
- On a New Class of -Valent Meromorphic Functions De...
- Chemical Composition and Antimicrobial Potential o...
- Microscopic Fluid Dynamic Simulation of the Metal ...
- A study of variations in the branching pattern of ...
- Role of triple phase computed tomography findings ...
- Metacognitive awareness- evaluation and implicatio...
- Exploring nutritional status, physical activity an...
- Difficult patients from the perspective of healthc...
- Outcome of albendazole therapy in the management o...
- Etiological study of generalized lymphadenopathy i...
- Knowledge, attitude and practices towards consumpt...
- Cognitive function and its association with level ...
- Prevalence of oral mucosal lesions and associated ...
- Retrospective study on predictive scoring system f...
- Eating disorders and anxiety among high school stu...
- Pediatric urolithiasis: What role does metabolic e...
- Importance of yoga in diabetes and dyslipidemia
- An analysis of ear discharge and antimicrobial sen...
- A study on relationship of facebook and game addic...
- Percutaneous nephrostomy or double J stenting, whi...
-
▼
Ιουλ 26
(50)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Τρίτη 26 Ιουλίου 2016
Implications of the diversity of class I HLA associations in psoriatic arthritis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου