Efficacy of tip cryotherapy in the treatment of Idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study.

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Efficacy of tip cryotherapy in the treatment of Idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study.

J Dermatolog Treat. 2016 Aug 5;:1-19

Authors: Laosakul K, Juntongjin P

Abstract
BACKGROUND: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine its efficacy.
OBJECTIVES: To evaluate the efficacy and side effects of tip cryotherapy in IGH treatment Material and methods: Total 101 lesions were included. 43 lesions were treated with cryotherapy and 58 lesions were assigned as control. A single session of tip cryotherapy was delivered and remained for 5 seconds. Colorimeter was used to measure lesional luminosity at baseline and then monthly until 4 months. Digital photographs were evaluated by two blinded dermatologists. In addition, patients' assessments and side effects were assessed.
RESULTS: Mean luminosity scale gradually decreased from baseline. Also, the score of the treated lesions has been significantly lower than that of the control lesions since week 8 (P = 0.005). At 4 months, dermatologists' assessment revealed that 82.3% of the treated lesions comparing to only 2% of the control showed more than 75% improvement (P < 0.001). Burning sensation was the most common side effect.
CONCLUSION: Tip cryotherapy appears to be an effective therapy with minimal adverse effect for IGH.

PMID: 27494272 [PubMed - as supplied by publisher]

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