Epidemiological profile and risk factors of HIV and HBV/HCV co-infection in Fujian Province, southeastern China

Abstract

Objective

This study aimed to investigate the epidemiological features of HIV-infected subjects co-infected with HBV/HCV in Fujian Province, southeastern China, and identify the risk factors.

Methods

Blood samples were collected from 2,028 HIV antibody-positive subjects in Fujian Province. Serum HBsAg and anti-HCV antibody were detected, and CD4⁺ T cell count was measured.

Results

Of the 2,028 subjects, the prevalence of HIV-HBV, HIV-HCV and HIV-HBV-HCV co-infections was 16.22%, 3.7% and 0.79%, respectively. Man (OR = 1.912, 95% CI: 1.371–2.667), key population (OR = 0.756, 95% CI: 0.57–0.976) and detainee (OR = 0.486, 95% CI: 0.259–0.909) were risk factors of HIV-HBV co-infection, and man (OR = 2.227, 95% CI: 1.096–4.525), minority (OR = 5.04, 95% CI: 1.696–14.98), junior high school or lower education (OR = 2.32, 95% CI: 1.071–5.025), intravenous drug use (OR = 38.46, 95% CI: 11.46–129.11) and detainee (OR = 5.687, 95% CI: 2.44–13.25) were risk factors of HIV-HCV co-infection. In addition, a lower mean CD4⁺ T cell count was measured in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects among the untreated individuals, while in the treated populations, a higher mean CD4⁺ T cell count was detected in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects.

Conclusion

HIV co-infection with HBV or HCV, notably HIV-HBV co-infection, is widespread in southeastern China. Hepatitis virus screening should be included in monitoring of HIV infection, and HIV and hepatitis virus co-infection should be considered during the development of HIV antiretroviral therapy scheme. This article is protected by copyright. All rights reserved

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