Liver function Assessment by Magnetic Resonance Imaging

Liver function assessment by hepatocyte specific contrast-enhanced MR is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate), signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labelled mebrofenin scintigraphy and indocyanine green clearance test. MRI assessment of liver function can enable diagnosis of cirrhosis, non-alcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, chemotherapy and radiotherapy related changes, which may be only visible on hepatobiliary phase images.

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