Long-term preclinical MRI alterations in sporadic Creutzfeldt-Jakob disease

Abstract

An asymptomatic 74-year-old woman, on follow-up for a carotid body tumour, showed MRI focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After one month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within three months. Prion protein gene sequence, molecular and neuropathological studies confirm the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. This article is protected by copyright. All rights reserved.

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