The relation between changes in thyroid function and anthropometric indices during long-term follow-up of euthyroid subjects: the Tehran Thyroid Study (TTS)

Objective

Uncertainties exist regarding the causal relationship between thyroid function tests (TFT) within the euthyroid range and anthropometric measures. This longitudinal cohort is aimed to examine the relationship between the two conditions.

Subjects and methods

Euthyroid participants of Tehran Thyroid Study (TTS) attending phase I (1999–2001) were included in this study and were followed up to phase IV (2008–2011). TSH and free T₄ (fT₄) levels as well as weight (Wt), waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) were measured at both phases.

Results

971 women and 784 men were included in the analysis. During 9.7years of follow-up, increases in TSH levels, Wt and WHR as well as a decrease in fT₄ level were observed. Multivariable regression analysis showed a significant relationship between TSH changes and alterations in WC in women (β=0.69, P=0.021) and men (β=0.61, P=0.038). Moreover, a significant negative association of fT₄ with changes in weight was documented (β=–0.49, P=0.001 in women and β=–0.56, P<0.001 in men). Additionally, we found a negative relationship between fT₄ and HC in men (β=–0.36, P=0.001).

Conclusion

In both genders, there was a positive relationship between changes in TSH and waist circumference and conversely a negative association of changes of fT₄ levels with weight over time.

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2bipGTp
via IFTTT