Publication date: August 2017
Source:Archives of Oral Biology, Volume 80
Author(s): Mengchen Wang, Man Qin, Bin Xia
ObjectiveThe aim of this study was to assess the role of ENAM rs3796703, LTF rs1126478, and TNF-α rs1800629 in high caries susceptibility.DesignThe present case–control study included 1005 unrelated children under 4 years old: 505 with severe caries (dmft index ≥4) and 500 who were caries-free (dmft index=0 and without white-spot lesions). Questionnaires were obtained from parents and gardians about the children's diet and oral behavioural habits. All the children received dental examinations and oral swabbing for human genomic DNA collection. ENAM rs3796703, LTF rs1126478, and TNF-α rs1800629 were genotyped by Sanger sequencing.ResultsThe frequency of the ENAM rs3796703T allele (6.7% in the caries group and 4.2% in the caries-free group), CT genotype (12.7% in the caries group and 8.4% in the caries-free group), TNF-α rs1800629 A allele (4.8% in the caries group and 6.8% in the caries-free group), and AG genotype (8.7% in the caries group and 13.2% in the caries-free group) were significantly different between the caries and caries-free groups (p<0.05). No significant difference was found in the LTF rs1126478 allele frequency and genotype distribution between the two groups. The ENAM rs3796703 CT genotype increased caries susceptibility by 60.9% compared to the CC genotype (β=0.746, OR=1.609), and the TNF-α rs1800629 AG genotype reduced caries susceptibility by 47.4% compared to the GG genotype (β=−0.642, OR=0.526). In terms of habits covariates, prolongation of night feeding time by 1 month increased caries susceptibility by 3.3% (β=0.033, OR=1.033); additionally, sweets and acidic drinks consumption 1–2 times per day increased caries susceptibility by 218.2% (β=1.158, OR=3.182), and consumption 3 or more times pe/r day increased susceptibility by 883.5% (β=2.286, OR=9.835) compared to non-consumption. Topical fluoride application decreased caries susceptibility by 43.0% (β=−0.562, OR=0.570).ConclusionsThe ENAM and TNF-α genes are likely associated with caries experience in Chinese children. The ENAM rs3796703 CT genotype might be involved in caries susceptibility, while TNF-α rs1800629 AG genotype might be involved in caries protection.
http://ift.tt/2nUJ6nd
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
Απριλίου
(6024)
-
▼
Απρ 07
(222)
- Ten-year survival outcomes for patients with nasop...
- Viral Reactivations and Associated Outcomes in Con...
- Outcome of Hematopoietic Cell Transplantation for ...
- Interplay Between the Skin Barrier and Immune Cell...
- Is IL-1β inhibition the next therapeutic target in...
- Efficacy of tofacitinib for the treatment of nail ...
- The effectiveness of treatments for androgenetic a...
- Yellow Fever Virus Modulates the Expression of Key...
- Development of mPMab-1, a Mouse–Rat Chimeric Antib...
- LpMab-23: A Cancer-Specific Monoclonal Antibody Ag...
- The association of Enamelin, Lactoferrin, and Tumo...
- The Rosai–Dorfman Disease: A Differential Diagnosi...
- Acquired Angioedema: A Rare Manifestation of Angio...
- A Rare Case of Basal Cell Adenocarcinoma of Paroti...
- Managing the Dorsum in Rhinoplasty
- Cartilage Scales Embedded in Fibrin Gel
- Dorsal Augmentation Using Autologous Costal Cartil...
- Understanding Approaches to the Dorsal Hump
- Dorsal Augmentation with Homologous Rib
- Aesthetics of the Nasal Dorsum: Proportions, Light...
- Safety of 2-Octyl Cyanoacrylate in Spreader Grafting
- Midvault Reconstruction in Primary Rhinoplasty
- Facial Augmentation using Expanded Polytetrafluoro...
- Treating the Deviated or Wide Nasal Dorsum
- Revision of the Nasal Dorsum
- Correcting Deviations of the Lower Third of the Nose
- Rhinoplasty Results Are Influenced by Non-nasal Fe...
- Dorsal Augmentation-Diced Cartilage Techniques: Th...
- Interest in Aesthetic Rhinoplasty Scale
- Dorsal Augmentation using Alloplastic Implants
- Absorbable Implant to Treat Nasal Valve Collapse
- Erratum: Hyaluronic Acid Fillers in Soft Tissue Re...
- The Importance of Facts and the Role of Academic P...
- Detection of endolymphatic hydrops using tradition...
- Reduced post-tonsillectomy bleeding rates through ...
- Correction to: Viral Immunol 2013;26:259–267
- MicroRNA-155 Deficiency in Kupffer Cells Ameliorat...
- Human Herpesvirus 6 Reactivation in DRESS With Acu...
- Octogenarian Liver Grafts Reaching Centennial Age ...
- Sleep-Disordered Breathing, Postoperative Delirium...
- Computational and In Vitro Experimental Investigat...
- Total Spinal Anesthesia Failure: Have You Assessed...
- How Long Is Too Long? The Prespiked Intravenous De...
- The Association of Frailty With Outcomes and Resou...
- Creation and Validation of an Automated Algorithm ...
- Anesthesiologists and Disaster Medicine: A Needs A...
- Surveying the Literature: Synopsis of Recent Key P...
- Generative Retrieval Improves Learning and Retenti...
- It Takes a Village to Deliver Effective and Effici...
- Sevoflurane Posttreatment Attenuates Lung Injury I...
- Does Bariatric Surgery Decrease Levothyroxine Requ...
- Postoperative Thyroglobulin and Neck Ultrasound Ar...
- Thyroid Nodules Do Not Increase in Size During Pre...
- Intensity of 18F-FDG Uptake in Metastatic Differen...
- Levothyroxine Therapy of Subclinical Hypothyroidis...
- Rare Cases of Differentiated Thyroid Cancer with L...
- Hyperthyroidism with Severe Liver Dysfunction Can ...
- In Patients with Congenital Hypothyroidism, Prolon...
- Could Measuring a Spectrum of Metabolites and Prot...
- Novel Anticoagulant Agents in the Perioperative Se...
- Erratum
- General anesthetic actions on GABA A receptors in ...
- Diagnostic Tools in Ocular Allergy
- Work productivity in rhinitis using cell phones: T...
- Whipple’s disease in granulomatous disguise: a cha...
- Not little adults: The uniqueness of the pediatric...
- CARD14-Mediated Activation of Paracaspase MALT1 in...
- Type I lnterferons Modulate CD8(+) T Cell Immunity...
- Bioinspired, biomimetic, double-enzymatic minerali...
- Procedure of informed assent/consent for clinical ...
- Off-label and unlicensed use in a pediatric hemato...
- Predicting outcomes for children with neuroblastoma
- GATA4 and GATA5 are potential tumor suppressors an...
- Pharmacologic unmasking of epigenetically silenced...
- Transabdominal wall lipoma
- Otolaryngology: Open Access..................OMICS...
- Adolescent anxiety: The effectiveness of psycholog...
- The impact of a lack of medical explanation for pa...
- Generalisation in Named Entity Recognition: A Quan...
- The effect of brief mindfulness training on distre...
- Healthy adjustment for new residents with dementia...
- Benchmarking predictions of allostery in liver pyr...
- Biosecurity for Translocations: Cirl Bunting (Embe...
- Neural Correlates of Inhibition in Children and Ad...
- The Effect of Age on the Underlying Abilities of M...
- Pain part 9: Trigeminal autonomic cephalalgias
- Genetic evidence challenges the native status of a...
- Freud reads Krafft-Ebing : the case of sadism and ...
- Recht en geweld
- Freuds Gentse connectie: Juliaan Varendonck (1879-...
- Molybdenum(VI) Dioxo Complexes Supported on stable...
- Renal microRNA- and RNA-profiles in progressive ch...
- Positron emission tomography study of the human hy...
- Impact of Respiratory Virus Infections in Exacerba...
- An atypical form of infantile meningococcal mening...
- Aorto-right ventricular fistula following transcat...
- Impact of Respiratory Virus Infections in Exacerba...
- Johns Hopkins Researchers Win Top Prizes, Honors a...
- An NLRP3 inflammasome-triggered Th2-biased adaptiv...
- Neurophysiological and clinical investigation of p...
-
▼
Απρ 07
(222)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου