3D black blood MR angiography of the carotid arteries. A simple sequence for plaque hemorrhage and stenosis evaluation

Publication date: Available online 16 June 2017
Source:Magnetic Resonance Imaging
Author(s): Monica Sigovan, Clément Bidet, Sébastien Bros, Loic Boussel, Laura Mechtouff, Philip M. Robson, Zahi A. Fayad, Antoine Millon, Philippe Douek
ObjectivesTo evaluate the diagnostic performance of a new three-dimensional T1-weighted turbo-spin-echo sequence (3D T1-w TSE) compared to 3D contrast-enhanced angiography (CE-MRA) for stenosis measurement and compared to 2D T1-w TSE for intra-plaque hemorrhage (IPH) detection.MethodsEighty three patients underwent carotid MRI, using a new elliptic-centric phase encoding T1-weighted 3D TSE sequence in addition to the clinical protocol.Two observers evaluated image quality, presence of flow artifacts, and presence of intra-plaque hemorrhage, and computed the NASCET degree of stenosis for CE-MRA and for the new sequence. Inter-observer agreement and correlation between 3D TSE and CE-MRA for NASCET stenosis was estimated using Cohen's kappa, and correlation using linear regression and Bland-Altman plots.Histology was performed on endarterectomy samples for 18 patients. Sensitivity and specificity of 2D and 3D TSE for IPH diagnosis were computed.Results3D TSE showed better image quality than 2D TSE (p<0.05). Interobserver agreement was good (kappa≥0.86). Correlation between 3D TSE and CE-MRA was excellent (R=0.95) for NASCET stenosis. Sensitivity and specificity for IPH diagnosis was 50% and 100% for 2D TSE and 100% and 83% for the 3D TSE.ConclusionsThe new 3D T1-w TSE allows both reliable measures of carotid stenosis, with a slight overestimation compared to CE-MRA (5%), and improved IPH identification, compared to 2D TSE.



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