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Δευτέρα 27 Νοεμβρίου 2017

First practical synthesis of novel 1-phosphonylated pyrrolo[1,2-a]pyrazine derivatives

Abstract

We present a convenient synthetic approach to novel 1-phosphonylated pyrrolo[1,2-a]pyrazine derivatives based in efficient three-component reactions. According to this method, N-functionalized 2-formylpyrrole derivatives are used as bifunctional coupling reagents in the reaction with dialkyl phosphites and amines to access to the target compounds.



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