BACKGROUND: Although the National Institutes of Health (NIH) invests $30 billion in research annually, many funded studies fail to generate results that can inform practice. The National Institutes of Health introduced a phased funding mechanism as one potential solution. Study-specific milestones are established for an initial pilot phase. We assess the utility of this phased approach through the ongoing Electroencephalography (EEG) Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) pragmatic clinical trial. The hypothesis of the trial is that EEG guidance of general anesthesia, through prevention of EEG suppression, can decrease postoperative delirium and its downstream negative sequelae. METHODS: In collaboration with study stakeholders, we identified critical milestones for the ENGAGES study, with themes common to many clinical trials. These themes include: regulatory tasks; enrollment targets; feasibility and impact of study intervention; primary outcome incidence; measurement reliability of primary outcome; and follow-up. Progress in achieving the milestones was assessed at regular intervals during the pilot phase by ENGAGES investigators, a National Institute on Aging program officer, and a nonpartisan research organization (Westat). RESULTS: Regulatory tasks, including institutional review board approval, infrastructure establishment, and trial registration, were completed on schedule. A total of 117 patients were randomized, exceeding the target by 51. The EEG-guided protocol was successfully implemented, and a relevant effect on anesthetic practice was demonstrated (decrease in median age–adjusted minimum alveolar anesthetic concentration from 0.93 to 0.78 [P
http://ift.tt/2C9N9nk
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
-
▼
Δεκεμβρίου
(3127)
-
▼
Δεκ 13
(426)
- Resuscitative endovascular balloon occlusion of th...
- The forgotten organ
- Sclerosing lipogranuloma presenting as movable mas...
- Early cutaneous eruptions after oral hydroxychloro...
- MRI screening of the internal auditory canal: Is g...
- Combined use of a nanocarbon suspension and 99mTc-...
- Microinvasive parathyroidectomy: Incremental impro...
- Nanoparticle delivery of RNA-based therapeutics to...
- An innovative solution for T-tube obstruction: The...
- Clinical implications of magnetic resonance imagin...
- Brain volume changes in hyposmic patients before a...
- Use of autologous adipose-derived mesenchymal stem...
- When should a level IIB neck dissection be perform...
- Effect of rural and urban geography on larynx canc...
- Trial of hyperthermic treatment for Bowen's diseas...
- Relationship between serum anti-varicella zoster v...
- Postmenopausal craniofacial hyperhidrosis
- IL-25 is involved in CTCL progression by establish...
- Regulation of MAVS activation through post-transla...
- Methotrexate and azathioprine in severe atopic der...
- Combined use of a nanocarbon suspension and 99mTc-...
- MRI screening of the internal auditory canal: Is g...
- Steroidpsychose als Folge einer regulären Hörsturz...
- Reply
- When to Stop Immunotherapy: First Response? Max Re...
- Distinctive cutaneous and systemic features associ...
- Perianal tuberculosis in an immunocompetent patient
- Epidermodysplasia verruciformis in an adult patien...
- Dermoscopy for discriminating between Trichophyton...
- Four cases of anti-Mi-2 antibody-positive dermatom...
- The Economics of Colon Cancer
- The Expanding Toolkit of Translating Ribosome Affi...
- Delayed Treatment with Histone Deacetylase Inhibit...
- Graded Elevation of c-Jun in Schwann Cells In Vivo...
- What Can Recordings in the Striatum Tell Us about ...
- FGF-FGFR Mediates the Activity-Dependent Dendritog...
- Activation of {gamma}-Secretase Trimming Activity ...
- Detailed Dendritic Excitatory/Inhibitory Balance t...
- This Week in The Journal
- The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic...
- Neuropeptide S Activates Paraventricular Oxytocin ...
- Interlayer Repulsion of Retinal Ganglion Cell Mosa...
- Sleep in Humans Stabilizes Pattern Separation Perf...
- Morphological Constraints on Cerebellar Granule Ce...
- Multimodal Imaging in Rat Model Recapitulates Alzh...
- Working Memory and Decision-Making in a Frontopari...
- Neural Representations of Hierarchical Rule Sets: ...
- Firefighter Skin Cancer and Sun Protection Practices
- Clinical Findings and Gene Expression in Balloon C...
- Tender Nodules on the Lower Legs
- Noninvasive Gene Expression Testing in Amelanotic ...
- Hypercoagulable Conditions and Calciphylaxis in Re...
- 15,000 Cases Reports Published
- Industry Influence in Dermatology Clinical Practic...
- The Most Beautiful People
- Chronic Urticaria in Children
- December 2017
- The Epidemic of Guns
- A Transgender Woman With Anogenital Lichen Sclerosus
- Industry Payments Among Dermatology Clinical Pract...
- Factors Associated With Chronic Urticaria in Children
- Treatment of Psychiatric Disorders and Skin-Restri...
- Sclerotherapy for Reticular Veins in the Lower Limbs
- Prescription-Strength Topical Steroids Sold Withou...
- Alcohol-Related Mortality in Patients With Psoriasis
- Industry Influence in Dermatology Clinical Practic...
- The Most Beautiful People
- Chronic Urticaria in Children
- Prescription-Strength Topical Steroids Sold Withou...
- December 2017
- The Epidemic of Guns
- A Transgender Woman With Anogenital Lichen Sclerosus
- Industry Payments Among Dermatology Clinical Pract...
- Dermatology in Epic Poetry—From Beowulf to The Ody...
- Factors Associated With Chronic Urticaria in Children
- Barber Recognition of Pseudofolliculitis Barbae an...
- Diagnostic Accuracy of Pediatric Teledermatology U...
- Sclerotherapy for Reticular Veins in the Lower Limbs
- Alcohol-Related Mortality in Patients With Psoriasis
- Joseph Goldberger—Public Health Champion and Inves...
- Resilience and Depression in Patients With Hidrade...
- Stevens-Johnson Syndrome and Toxic Epidermal Necro...
- Long-term Change in the Risk of Skin Cancer After ...
- Hypophysenadenome – nicht immer benigner Natur
- Pepsin in saliva as a diagnostic biomarker in lary...
- In vivo imaging the motility of monocyte/macrophag...
- Cerebral blood flow changes after radiation therap...
- Awake mapping is not an additional surgical techni...
- Isolated and repeated stroke-like episodes in a mi...
- Predictors of post-stroke body temperature elevation
- As the first sign of multiple sclerosis, eight-and...
- PEG Hydrogel Containing Calcium-Releasing Particle...
- Clinically Advancing and Promising Polymer-based T...
- Work Outcomes in Patients Who Stay at Work Despite...
- Rational evaluation of the therapeutic effect and ...
- REAL TIME PCR TO EVALUATE HSV-2 SHEDDING FROM ANAL...
- Recovery of Hepatitis C Specific T-cell Responses ...
- Characterization of a Norovirus-specific monoclona...
- Fachärztliches Basiswissen zur Wirksamkeit von Hör...
- Longitudinal assessment of rabbit renal fibrosis i...
-
▼
Δεκ 13
(426)
- ► Σεπτεμβρίου (2173)
-
▼
Δεκεμβρίου
(3127)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου