Optogenetic activation of granule cells in the dorsal Dentate Gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens

Publication date: Available online 12 December 2017
Source:Neuroscience Research
Author(s): Laurent Tritschler, Mazen A. Kheirbek, Yannick Le Dantec, Indira Mendez-David, Jean-Philippe Guilloux, Charlène Faye, Julie Doan, Thu-Ha Pham, René Hen, Denis J. David, Alain M. Gardier
The dentate gyrus (DG) has distinct roles along its dorso-ventral axis. In the mouse, we recently demonstrated that dorsal DG (dDG) stimulation enhances exploratory behavior (Kheirbek et al., 2013). Dopamine (DA) release in the Nucleus Accumbens (NAcc), which belongs to the reward system, could be a key target of dDG mediating this motivation-related behavior. Here, an optogenetic stimulation of either ventral (vDG) or dDG granule cells was coupled with NAcc DA release monitoring using in vivo microdialysis. Only dDG stimulation enhanced NAcc DA release, indicating differential interconnections between dDG and vDG to the reward system.



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