A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma

Publication date: Available online 4 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Kedir N. Turi, Lindsey Romick-Rosendale, Kelli K. Ryckman, Tina V. Hartert
As asthma is a disease that results from host x environment interactions, an approach which allows assessment of the impact of the environment on the host is needed to understand disease. Metabolomics has appealing potential as an application to study pathways to childhood asthma development. The objective of this review is to provide an overview of metabolomics methods, and their application to understanding host x environment pathways in asthma development. We reviewed recent literature on advances in metabolomics and their application to study pathways to childhood asthma development. We highlighted 1) the potential of metabolomics in understanding the pathogenesis of disease and the discovery of biomarkers, 2) choice of metabolomics techniques, biospecimen handling, and data analysis, 3) the application to studying the role of environment on asthma development, 4) review of metabolomics applied to the outcome of asthma, 5) recommendations for application of metabolomics based –omics data integration in understanding disease pathogenesis, and 6) limitations. In conclusion metabolomics allows use of biospecimens to identify useful biomarkers and pathways involved in disease development, and subsequently to inform a greater understanding of the disease pathogenesis and endotypes, and predicting the clinical course of childhood asthma phenotypes.



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