A case of neuropathic pain in monoclonal mast cell activation syndrome

Neuropathic pain is an uncommon symptom associated with mast cell disorders but can significantly impact quality of life. Mast cells are known to be gatekeepers of nociception and play an important role in the development of neuropathic pain in the central and peripheral nervous system1. Although musculoskeletal pain has been associated with mast cell disorders2, neuropathic pain associated with mast cell disorders and its management has not been well described in the literature. We present a patient with neuropathic pain associated with monoclonal mast cell activation syndrome (MMAS) and review the agents used in his treatment.

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