BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats. METHODS: Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group. Expression of genes for inflammatory mediators was quantified in the spinal dorsal horn. In the final experiment, morphine was administered before laparotomy for 7 days. RESULTS: We found that morphine treatment after laparotomy extended postoperative pain by more than 3 weeks (time × treatment: P
https://ift.tt/2GDo9tD
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
▼
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
-
▼
Μαρτίου
(3597)
-
▼
Μαρ 29
(99)
- Microanatomical Nerve Architecture of 6 Mammalian ...
- Application of precision medicine to the treatment...
- Avenues for research in food allergy prevention: u...
- How to diagnose food allergy
- How to predict and improve prognosis of food allergy
- Phenotypes/endotypes-driven treatment in asthma
- How to prevent food allergy during infancy: what h...
- Current opinion in allergy and clinical immunology...
- Effect of Epley, Semont Maneuvers and Brandt–Darof...
- Treatment of Radiation and Cisplatin Induced Toxic...
- Postoperative aRCH With Cisplatin Versus aRCH With...
- Proton Beam Therapy in the Treatment of Esophageal...
- Evaluation of an Oral Care Programme for Head and ...
- The Inclined Position in Case of Respiratory Disco...
- Effect of Epley, Semont Maneuvers and Brandt–Darof...
- Toward universal influenza virus vaccines: from na...
- Butterfly cartilage tympanoplasty outcomes: A sing...
- Tube patency: Is there a difference following otic...
- Differential diagnoses of diaper dermatitis
- Introduction: Hot topics in neonatal skin care fro...
- Issue Information ‐ Table of Contents
- Prevention and treatment of diaper dermatitis
- Issue Information ‐ Editorial Board
- Skin barrier in the neonate
- Subclassification of Bethesda Atypical and Follicu...
- Getting Your Toddler to Eat
- Butterfly cartilage tympanoplasty outcomes: A sing...
- Tube patency: Is there a difference following otic...
- Editorial Board
- The Impact of Postreperfusion Syndrome on Acute Ki...
- Anesthetics Influence Mortality in a Drosophila Mo...
- Database Quality and Access Issues Relevant to Res...
- Dexamethasone as an Adjuvant for Caudal Blockade i...
- Time for a Fresh Approach to Examining Factors Ass...
- Repeated Morphine Prolongs Postoperative Pain in M...
- A Dedicated Acute Pain Service Is Associated With ...
- Evidence Basis for Regional Anesthesia in Ambulato...
- Determination of Geolocations for Anesthesia Speci...
- Intravenous Acetaminophen Does Not Reduce Inpatien...
- Clonidine Effect on Pain After Cesarean Delivery: ...
- Changes in International Normalized Ratios After P...
- A Novel Approach to the National Resident Matching...
- Tubular Neck Mass
- Pulsatile Tinnitus With Imaging
- Standardized Margin Assessment Is Needed Before Im...
- Standardized Margin Assessment Is Needed Before Im...
- Postoperative Facial Baroparesis While Flying
- Preoperative Facial Nerve Mapping and Pediatric Fa...
- Thyroidectomy Practice After Implementation of 201...
- Possible involvement of acetylcholine-mediated inf...
- Media Advisory: Johns Hopkins Hospital Raising the...
- Mast cell disorders: Protean manifestations and tr...
- MULTIPLE SOLID ORGAN TRANSPLANTATION IN TELOMEROPA...
- The Third International Consensus Guidelines on th...
- Unusual Case of Vogt-Koyanagi-Harada Disease Assoc...
- Reduction of bilateral dislocation of TMJ and Rend...
- Use of sternal plate for pectus excavatum repair i...
- Laparoscopic choledochoscopy with Ambu® aScope 3™ ...
- Case 10-2018: An 84-Year-Old Man with Painless Uni...
- Light on fumaric acid esters therapy for psoriasis
- Interleukin‐36 in hidradenitis suppurativa: eviden...
- Efficacy and safety of autologous haematopoietic s...
- Ixekizumab treatment for psoriasis: integrated eff...
- Towards global consensus on core outcomes for hidr...
- Image Gallery: Symmetric reticular scarring of the...
- Image Gallery: A hard ‘pebbly’ plaque stuck on the...
- Is new better than tried and tested? Topical atopi...
- Image Gallery: Dermatophytic pseudomycetoma caused...
- 在系统性硬化病中进行自身造血干细胞移植的功效和安全性:文献的系统性评述
- Corrigenda
- Corrigenda
- 伊赛珠单抗对银屑病的治疗:三项双盲对照研究的综合药效分析(发现‐1、发现‐2、发现‐3)
- 化脓性汗腺炎中的IL‐36:独特的促炎性作用的证据和炎症循环发展的关键因素
- 化脓性汗腺炎研究的核心结果的全球共识:历史性共识会议I和II的更新
- Corrigenda
- Cell delivery using microneedle devices: a new app...
- 黑素原生成的旁分泌调节
- The heterogeneous mutational landscape of pustular...
- Corrigenda
- Responses in patients receiving sequential paclita...
- Tumor lysate-based vaccines: on the road to immuno...
- Palatal Polymorphous Adenocarcinoma with High-Grad...
- Palatal Polymorphous Adenocarcinoma with High-Grad...
- Design of flexible and adaptable healthcare buildi...
- (Pro)renin Receptor Inhibition Reprograms Hepatic ...
- Materials library collections as tools for interdi...
- Clinical correlates of hypoglycaemia over 4 years ...
- The safety of live-attenuated vaccines in patients...
- Cerebrospinal fluid in the differential diagnosis ...
- Symptomatic Treatment of Vascular Cognitive Impair...
- A spliced latency-associated VZV transcript maps a...
- Mechanistic insights of Li+ diffusion within doped...
- A software tool 'CroCo' detects pervasive cross-sp...
- Cardiovascular autonomic responses in pre- and pos...
- Do no harm: Observation only in a 98-year-old woma...
- Original Research By Young Twinkle Students (ORBYT...
- Hippocampus, Retrosplenial and Parahippocampal Cor...
- Lived experiences of negative symptoms in first-ep...
- Palatal Polymorphous Adenocarcinoma with High-Grad...
-
▼
Μαρ 29
(99)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου