Purpose of review The review puts new information on geno- and phenotype of salivary duct carcinoma (SDC) in the perspective of the updated 2017 WHO classification. Recent findings The proportion of SDC is increasing. This may be because of a true rise in incidence, but certainly to better diagnostic tests and changed WHO definitions. In this light, a substantial proportion of carcinoma expleomorphic adenoma is now attributed to the category of SDC. 'Low-grade SDC' and 'SDC in-situ' of the former WHO classification, are now named low-grade and high-grade intraductal carcinoma (IDC), respectively. Recent series quantify biologic aggressiveness: perineural growth, vascular invasion, and extracapsular extension in lymph node metastasis are each observed in two out of three patients with SDC. Most patients die within 3 years, but once 5-year disease-free survival is reached, further disease activity is exceptional. The typical molecular biological profile with high human epidermal growth factor receptor 2 and androgen receptor expression is increasingly successfully exploited in clinical trials for advanced SDC. Summary The aggressive SDC is increasingly diagnosed. Despite intensive combined surgery and radiation therapy, many patients recur, for whom new bullets, targeting the molecular biological mechanisms, are the subject of ongoing clinical trials.
http://ift.tt/2p1oHOY
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
▼
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
-
▼
Μαρτίου
(3597)
-
▼
Μαρ 09
(162)
- Myxoma of the mandibular condyle: Report of a rare...
- Treatment and frequency of follow-up of BCC patien...
- Immunohistochemical identification of nail matrix ...
- A case of subepidermal autoimmune bullous disease ...
- Patch Testing in Gastrointestinal Diseases – A Sys...
- Contact hypersensitivity in rosacea – a report on ...
- Reply to: Kubiak K. And al. Endosymbiosis and its ...
- The iris signal: blue periphery, tan collaret and ...
- 5 alpha-reductase inhibitor treatment for frontal ...
- (Meth)acrylate allergy: frequently missed?
- Mutilating male genital Crohn's without gastrointe...
- Long-Term Optimization of Outcomes With Flexible A...
- Erythromelalgia: improvement in pain with transcra...
- Major prognostic factors for recurrence and surviv...
- Blunt cannula subcision is more effective than Nok...
- Clinical evaluation of simultaneously applied mono...
- Antiaging and antioxidant effects of topical autop...
- Should all patients with hyperparathyroidism be sc...
- Interleukin-31 and interleukin-31 receptor–new the...
- Intestinal-type adenocarcinoma of the sinonasal tr...
- Reducing morbidity and complications after major h...
- Salivary duct carcinoma
- Nature and role of surgical margins in transoral l...
- Free flaps for head and neck cancer in paediatric ...
- Oncologic and functional outcomes of patients trea...
- Editorial introduction
- Synovial sarcomas of the upper aero-digestive trac...
- Orbital exenteration for sinonasal malignancies: i...
- Detection of surgical margins in oral cavity cance...
- The recurrent pleomorphic adenoma conundrum
- Impact of 3D virtual planning on reconstruction of...
- Immunotherapy for recurrent/metastatic head and ne...
- Managing Your Anesthesiology Practice for the Future
- Improvement of skin lesions and life quality in mo...
- Erratum
- Pediatric Anatomy: Nose and Sinus
- Endoscopic Management of Congenital Dacryocystocele
- Surgical Management of Inferior Turbinate Hypertrophy
- Transnasal Repair of Congenital Choanal Atresia
- Pediatric Septoplasty
- Introduction: The simple act of breathing
- Columellar Reconstruction in Children
- Balloon Catheter Sinuplasty in Pediatric Chronic R...
- Pyriform Aperture Stenosis Repair in Infants
- Pediatric Sinus Surgery for Chronic Rhinosinusitis
- Survival in patients with submandibular gland carc...
- Combined human papillomavirus typing and TP53 muta...
- Patterns of recurrence in oral tongue cancer with ...
- Polyethylene glycol fusion associated with antioxi...
- Presence of lytic Epstein-Barr virus infection in ...
- Second primary squamous cell carcinoma in patients...
- Treatment with anti-Sclerostin antibody to stimula...
- Comparison of incidental versus palpable thyroid n...
- Skeletal muscle cells actively shape (auto)immune ...
- Clinical and experimental evidence for targeting C...
- The role of capillaroscopy and thermography in the...
- Optimizing conventional DMARD therapy for Sjögren'...
- The value of Autoimmune Syndrome Induced by Adjuva...
- Contribution of sex steroids and prolactin to the ...
- A methodological review of induced animal models o...
- Letter to the editor: Autoimmune pathogenic mechan...
- Solid phase assays versus automated indirect immun...
- Perspective: Scientific and ethical concerns perta...
- Cryoglobulins: An update on detection, mechanisms ...
- Association between allelic variants of the human ...
- Evaluating Hearing Loss in Patients Undergoing Sec...
- New-onset atrial fibrillation: an update
- Occurrence of deoxynivalenol and zearalenone in br...
- Eesti välispoliitika algusaegadest: Jaan Tõnissoni...
- Orientation-Selective Retinal Circuits in Vertebrates
- The Global Seed Market, Competition Law and Intell...
- Comprehensive Use of Curvature for Robust and Accu...
- Public Policy Considerations in Competition Enforc...
- Facilitation of ischaemia-induced ventricular fibr...
- The Interplay of Institutions. Linkages between En...
- Kaks majorit kahel pool Läänemerd: Väljaöeldu ja v...
- Setting and Strength of Brushite Cements with Vary...
- Otoferlin acts as a Ca2+ sensor for vesicle fusion...
- Global Governance of Antitrust and the Need for a ...
- Heterogeneous localisation of membrane proteins in...
- "Vexatious"/"Sham" Litigation in EU and US Antitru...
- Review of the Diagnosis and Treatment of Periodic ...
- High motor variability in DYT1 dystonia is associa...
- Preterm delivery and small-for-gestation outcomes ...
- Global Food Value Chains and Competition Law BRICS...
- Updating the EU Internal Market Concept
- Who’s Asking? Native Science, Western Science, and...
- Status of the FETS Project
- Hodgkins Lymphoma presenting as an obstructing end...
- Acute glomerulonephritis secondary to Streptococcu...
- An Itch You Can’t Scratch: Researchers Find “Itch ...
- Tailored Y-stent on the secondary carina for recur...
- Essential Issues for Pregnancy Counseling in Renal...
- Acute antibody-mediated rejection one week after l...
- A novel subcutaneous site of islet transplantation...
- Speech Perception Skills of Hindi Speaking Childre...
- Improvement of skin lesions and life quality in mo...
- Erratum
- The role of simulation training in anesthesiology ...
- Zebrafish as a model for kidney function and disease
-
▼
Μαρ 09
(162)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου