Αρχειοθήκη ιστολογίου

Πέμπτη 5 Απριλίου 2018

Risk factors for salivary gland cancers in France: Results from a case-control study, the ICARE study

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Publication date: May 2018
Source:Oral Oncology, Volume 80
Author(s): Loredana Radoï, Christine Barul, Gwenn Menvielle, Matthieu Carton, Mireille Matrat, Marie Sanchez, Corinne Pilorget, Michel Velten, Isabelle Stücker, Danièle Luce
ObjectivesEpidemiological studies on the risk factors for salivary gland cancers (SGC) are rare, concern a small sample size, and show inconsistent results. The aim of the present work was to analyze several risk factors for SGC, using the data from the ICARE study, a multicenter, population-based case-control study.Materials and methodsData from 73 SGC cases and 3555 controls were collected using a standardized questionnaire on lifestyle habits, personal and family medical history, and lifetime occupational history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regressions.ResultsTobacco use and alcohol consumption were not associated with the risk of SGC. A history of head and neck cancer or that of cervicofacial radiotherapy was associated with a higher risk of SGC (OR = 17.06, 95% CI: 4.34–67.05, and OR = 31.74, 2.48–405.25, respectively). Significantly increased risks were observed for some occupations: waiter (OR = 2.94, 1.11–7.78), charworker (OR = 3.02, 1.38–6.60), electrical and electronic equipment assembler (OR = 7.16, 2.02–25.38), plumber (OR = 3.95, 1.33–11.67), electric arc welder (OR = 6.15, 1.76–21.48), sheet-metal worker (OR = 2.89, 1.01–8.32), building painter (OR = 3.42, 1.01–11.49), and material handling equipment operator (OR = 5.05, 1.71–14.84). Results for industries were consistent with those observed for occupations.ConclusionOur results showed that a history of head and neck cancer, cervicofacial radiotherapy, and several occupations and industries, were associated with an increased risk of SGC. Further studies with larger sample sizes are indicated to confirm our results.



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