The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xiang, X; Piers, TM; Wefers, B; Zhu, K; Mallach, A; Brunner, B; Kleinberger, G; ... Haass, C; + view all Xiang, X; Piers, TM; Wefers, B; Zhu, K; Mallach, A; Brunner, B; Kleinberger, G; Song, W; Colonna, M; Herms, J; Wurst, W; Pocock, JM; Haass, C; - view fewer (2018) The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration , 13 (1) , Article 49. 10.1186/s13024-018-0280-6 . Green open access

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