CD103 negative memory T cells may play important roles in making regulatory T cell‐enriched environments in skin tumors

Abstract

Human skin contains resident memory T cells (T_RM) and central memory T cells (T_CM)^1‐3. T_RM are characterized by CD69 expression and can be divided into 2 subpopulations: CD103⁺T_RM and CD103^‐T_RM. Although both T_RM and T_CM showed antitumor efficacy in a mouse model⁴, little is known about their role in human skin cancer.

We obtained T cells from basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (SCC), the adjacent skin, and the distant normal skin for flow cytometry.

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