Chemoradiotherapy could improve overall survival of patients with stage IV cutaneous squamous cell carcinoma: analysis of 34 cases

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common non‐melanoma skin cancer, comprising approximately 20% of all skin malignancies¹. The prognoses of patients with unresectable disease, such as locally advanced tumour or distant metastases, are known to be relatively poor due to lack of effective standardized systemic therapies^2,3. When surgery is not feasible, non‐surgical approaches such as chemotherapy, radiation therapy (RT), and chemoradiotherapy (CRT; chemotherapy with radiation), are considered as alternative treatments².

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