Purpose of review: The development of monoclonal antibody-based biologics targeted at inhibition of the Th2 cytokines interleukin-4, interleukin-5 and interleukin-13 represent potentially effective treatments for asthma and allergic diseases. This short review is based on English-language original articles in PubMed or MedLine that reported significant clinical findings on the evidence demonstrating the effectiveness or otherwise of the targeting of interleukin-4, interleukin-5 or interleukin-13 in asthma or allergic disease. Recent findings: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level requiring specifically targeted treatments to block the key pathways of the disease. It is becoming apparent that significant clinical effects with anticytokine-based biologic therapies are more likely in carefully selected patient populations that take asthma phenotypes into account. Biologics aimed at interleukin-4/13, interleukin-5 or immunoglobulin E are potentially effective treatments for patients with difficult to treat allergic disease. The development of reproducible and straightforward discriminatory biomarkers may aid identification of those patients most likely to benefit from treatment with these expensive interventions. Summary: Overall these biologics-based therapies are effective treatments for difficult to treat asthma and allergic disease with a safety profile comparable with placebo in the majority of published studies.
http://ift.tt/2pL48rL
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
▼
Μαΐου
(6766)
-
▼
Μαΐ 05
(258)
- HIF-1α, MDM2, CDK4, and p16 expression in ischemic...
- A rare mutation in the F12 gene in a patient with ...
- Inadequacy of current pediatric epinephrine autoin...
- Re-thinking the Migration of Cariban-Speakers from...
- Nocturnal sleep architecture is altered by sleep b...
- Is caffeic acid phenethyl ester more protective th...
- Influence of masticatory function, dental caries a...
- A sustained increase of plasma fibrinogen in sudde...
- Decreased clinic visits for acute respiratory infe...
- Retrograde Parotidectomy and facial nerve outcomes...
- A rare mutation in the F12 gene in a patient with ...
- Diagnostic challenges, the evaluation of antibioti...
- Managing dysphagia in trachesotomized patients: wh...
- Voice and swallowing outcomes for adults undergoin...
- Behaviour change technique taxonomy: a method of d...
- Assessing asthma in the otolaryngologist's office
- Application of telepractice for head and neck canc...
- Voice outcomes for early laryngeal cancer
- Patient adherence to swallowing exercises in head ...
- Immunotherapy for food allergy
- Editorial introductions
- Social and quality of life impact using a voice pr...
- Biologics for asthma and allergy
- Speech and swallowing outcomes following oral cavi...
- Allergic laryngitis: unraveling the myths
- Voice outcomes post total laryngectomy
- US antibiotic stewardship and penicillin allergy
- Trombose seio lateral
- Retrograde Parotidectomy and facial nerve outcomes...
- A sustained increase of plasma fibrinogen in sudde...
- Decreased clinic visits for acute respiratory infe...
- Predictors of failure of DISE-directed adenotonsil...
- Poppers retinopathy
- Use of ticagrelor in human pregnancy, the first ex...
- Steroid unresponsive anti-NMDA receptor encephalit...
- Actinomyces meyeri brain abscess following dental ...
- Pleural effusion caused by a malpositioned umbilic...
- Cutaneous and pleural involvement in a patient wit...
- Molecular detection of Schizophyllum commune in a ...
- Rothia aeria: a great mimicker of the Nocardia spe...
- Potential involvement of Campylobacter curvus and ...
- Maxillary sinusitis with pulmonary tuberculosis
- Calvarial and cutaneous metastasis as the primary ...
- Fatal Bipolaris spicifera infection in an immunosu...
- Subcutaneous endometriosis: a rare cause of deep d...
- Quetiapine-induced manic episode: a paradox for co...
- Enterobius vermicularis infection of the ovary
- Heterotopic ossification of the elbows in a major ...
- Primary disseminated extrahepatic abdominal hydati...
- Autoimmune pernicious anaemia as a cause of collap...
- Still dizzy after all these years: a 90-year-old w...
- Cardiac arrhythmias associated with umbilical veno...
- An Evaluation of the Surgical Trauma to Intracochl...
- Perforated acute appendicitis with no peritonitis ...
- Visceral artery pseudoaneurysms: two case reports ...
- Authors’ reply: changes in gustatory function in p...
- Nasal nitric oxide as biomarker in the evaluation ...
- The RESPECT Project in the Rear-View Mirror: Past,...
- Intracochleäres Schwannom
- Prevalence of hearing loss in Northern and Souther...
- Vorbereitung für die Facharztprüfung HNO
- Feasibility of the head-mounted display for ultras...
- Intrathecal morphine for postoperative pain contro...
- A matched case–control comparison of hospital cost...
- Tongue-out versus tongue-in position during Intens...
- Discovery of novel nonmuscle myosin II inhibitors ...
- The diversity of techniques to study electrochemic...
- Discovery of novel nonmuscle myosin II inhibitors ...
- Improved synthesis and comparative analysis of the...
- Undecylenic acid: a valuable and physiologically a...
- Insights into the myosin II inhibitory potency of ...
- Rapid trifluoromethylation and perfluoroalkylation...
- Management of Periprosthetic Hip and Knee Joint In...
- Effect of Adalimumab on Visual Functioning in Pati...
- Neuromuscular reinnervation efficacy after nerve r...
- Creating sustainable cities one building at a time...
- Novel approaches to iron chelation therapy: novel ...
- Role of BK channels in macrophage activation
- Structural and Biochemical Studies on Cohesion Est...
- Learning to Read and Spell in Chinese: The Role of...
- Qualitatively Different Ways of Experiencing Learn...
- Modelling progression and heterogeneity in Alzheim...
- Retirement, cardiovascular disease and its risk fa...
- Mitochondrial quality control: Cell-type-dependent...
- Documentary and its Afterlives: California in Cata...
- Political Equality, Firm Size and the Choice of So...
- Novel approaches in adolescent obesity management
- Fault interaction processes and continental extens...
- Multidisciplinary team meetings in cancer care: a ...
- MPV17 Loss Causes Deoxynucleotide Insufficiency an...
- Development and Application of Functional Magnetic...
- Towards a reception history for 'Beowulf' in the c...
- Skin prick test is more useful than specific IgE f...
- Optical coherence tomography of the Kayser-Fleisch...
- A solitary fibrous tumour mimicking an aggressive ...
- Coffee and autoimmunity: More than a mere hot beve...
- Pathogenesis of Cutaneous Lupus Erythema Associate...
- Peripheral nervous system involvement in systemic ...
- Integrated Diagnosis Project for Inflammatory Myop...
- Autoimmune diseases and their relation with immuno...
-
▼
Μαΐ 05
(258)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου