In Vitro - In Vivo Discordance with Humanized Piperacillin-Tazobactam Exposures against Piperacillin-Tazobactam-Resistant/Pan-{beta}-Lactam-Susceptible Klebsiella pneumoniae [PublishAheadOfPrint]

Recent findings have identified K. pneumoniae strains that are pan-β-lactam-susceptible (PBL-S), but piperacillin-tazobactam-resistant (TZP-R) in vitro. We assessed the efficacy of a humanized exposure of TZP against 12 TZP-R/PBL-S K. pneumoniae isolates in an immunocompromised murine lung infection model. Discordance between the in vitro resistance profile and the in vivo efficacy of human simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications these TZP-R/PBL-S strains.

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