There is currently enormous interest in the beneficial effects of aerobic exercise on a wide range of brain functions including mood, memory, attention, motor/reaction times, and even creativity. Understanding the immediate effects of a single bout of exercise is the first step to understanding how the positive effects of exercise may accrue over time to cause long-lasting changes in select brain circuits.
According to principal investigator Wendy A. Suzuki, PhD, Professor of Neural Science and Psychology in the Center for Neural Science, New York University, "Exercise interventions are currently being used to help address everything from cognitive impairments in normal aging, minimal cognitive impairment (MCI), and Alzheimer's disease to motor deficits in Parkinson's disease and mood states in depression. Our review highlights the neural mechanisms and pathways by which exercise might produce these clinically relevant effects."
Caption: What is the relationship between the central neurochemical changes following acute exercise that have
mainly been described in rodents and the behavioral changes seen after acute exercise that have mainly been
described in humans? Credit: Henriette van Praag (photo on left); MarathonFoto (photo on right).
The investigators summarized a large and growing body of research examining the changes that occur at the cognitive/behavioral, neurophysiological, and neurochemical levels after a single bout of physical exercise in both humans and animals. They reviewed brain imaging and electrophysiological studies, including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), functional near-infrared spectroscopy (fNIRS), and transcranial magnetic stimulation (TMS). They then turned to neurochemical studies, including lactate, glutamate and glutamine metabolism, effects on the hypothalamic-pituitary- adrenal (HPA) axis through cortisol secretion, and neurotrophins such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), and vascular endothelial growth factor (VEGF). Neurotransmitter studies of monoamines (dopamine, serotonin, epinephrine and norepinephrine), acetylcholine, glutamate and gamma-aminobutyric acid (GABA) were reviewed, as well as neuromodulators such as endogenous opioids and endocannabinoids.
This extensive review resulted in three main observations. First, the most consistent behavioral effects of acute exercise are improved executive function, enhanced mood, and decreased stress levels. Second, neurophysiological and neurochemical changes that have been reported after acute exercise show that widespread brain areas and brain systems are activated. Third, one of the biggest open questions in this area is the relationship between the central neurochemical changes following acute exercise, that have mainly been described in rodents, and the behavioral changes seen after acute exercise reported in humans. Bridging this gap will be an important area of future study.
Co-author Julia C. Basso, PhD, post-doctoral research fellow, Center for Neural Science at New York University, commented, "The studies presented in this review clearly demonstrate that acute exercise has profound effects on brain chemistry and physiology, which has important implications for cognitive enhancements in healthy populations and symptom remediation in clinical populations."
# # #NOTES FOR EDITORS
"The Effects of Acute Exercise on Mood, Cognition, Neurophysiology and Neurochemical Pathways: A Review," by Julia C. Basso and Wendy A. Suzuki (DOI: 10.3233/BPL-160040), openly available at http://ift.tt/2pCAiE8, Brain Plasticity, Volume 2, Issue 2 (2017). Contact Diana Murray, IOS Press, at +1 718-640-5678, d.murray@iospress.com for additional information. Journalists wishing to interview the authors should contact Wendy Suzuki, at +1 212-998-3734 or wendy@cns.nyu.edu.
ABOUT BRAIN PLASTICITY
Brain Plasticity publishes peer-reviewed original articles, reviews, and short communications on all aspects of neurogenesis, gliogenesis, and synaptic plasticity, from development to the adult. This includes research articles or reviews on modifications to neural circuits in the developing and adult brain, whether by learning or physical activity, spine formation, changes in neural structure, changes in neural networks, new cell division, as well as response of the CNS to experimental injuries, neurodevelopmental and neurodegenerative disorders. Papers adopting fresh conceptual approaches on specification and function at the molecular and cellular levels, neural circuits, systems and behavioral levels are encouraged. http://ift.tt/2sgKOnO.http://ift.tt/2sgKOnO
ABOUT IOS PRESS
Celebrating its 30 th anniversary, IOS Press (www.iospress.com) is headquartered in Amsterdam with satellite offices in the USA, Germany, India and China and serves the information needs of scientific and medical communities worldwide. IOS Press now publishes over 100 international journals and about 75 book titles each year on subjects ranging from computer sciences and mathematics to medicine and the natural sciences.
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