111In-DTPA-Octreotide SPECT (OctreoScan) Uptake in Metastatic Renal Cell Carcinoma to the Pancreas

Abstract We report a case of late presentation of metastatic renal cell carcinoma (RCC) demonstrating intense 111In-DTPA-octreotide uptake in pancreas without recurrence at the primary site. Immunohistochemistry study revealed somatostatin receptor subtype 2 of metastatic RCC preferentially expressed on tumor endothelial cells. The typical hypervascular features of RCC with intense homogeneous contrast enhancement in the arterial phase on CT should raise the possibility of metastatic RCC. This case illustrates that RCC can demonstrate high octreotide uptake in abdominal metastases. Received for publication August 21, 2017; revision accepted October 26, 2017. All authors contributed to care of the patient and wrote and approved the report. Conflicts of interest and sources of funding: K.C. is supported by NIHR Academic Clinical Fellowship. None declared to all other authors. Correspondence to: Kenneth Chan, MBBS, MRCP, Department of Nuclear Medicine, Royal Free NHS Foundation Trust, London, NW3 2QG, United Kingdom. E-mail: kennethchan1@nhs.net. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

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