Publication date: Available online 23 November 2017
Source:The Journal of Emergency Medicine
Author(s): Kristy Williamson, Gabriel Bredin, Jahn Avarello, Sandeep Gangadharan
BackgroundBronchiolitis is one of the most common disorders of the lower respiratory tract in infants. While historically diuretics have been used in severe bronchiolitis, no studies have looked directly at their early use in children in the emergency department.ObjectiveThe primary objective of this study was to determine whether a single early dose of a diuretic in infants with moderate to severe bronchiolitis would improve respiratory distress. Secondary objectives examined whether it reduced the use of noninvasive ventilation and hospital length of stay.MethodsPatients diagnosed with clinical bronchiolitis were enrolled at a tertiary care, academic children's hospital over a 3-year period. This was a double-blind, randomized controlled trial in which subjects were randomly assigned to either furosemide or placebo. Respiratory rate and oxygen saturation at the time of medication delivery and at 2 and 4 h post-intervention were recorded, as well as other data. Exact logistic regression was used to examine associations.ResultsThere were 46 subjects enrolled and randomized. There was no difference in respiratory rates, measured as a decrease of ≥ 25%, at both 2 and 4 h after intervention between furosemide and placebo groups (odds ratios 1.13 and 1.13, respectively). There was also no difference in oxygen saturation, intensive care unit admission rate, or hospital length of stay between groups.ConclusionsWhile theoretically a single dose of a diuretic to reduce lung fluid would improve respiratory distress in children with bronchiolitis, our randomized controlled medication trial showed no difference in outcomes. ClinicalTrials.gov ID: NCT02469597.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2BhXBYs
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
- ► Δεκεμβρίου (3127)
-
▼
Νοεμβρίου
(6729)
-
▼
Νοε 27
(377)
- Impact of Helicobacter pylori on Alzheimer's disea...
- Detection of Helicobacter pylori in stool samples ...
- Pharmacokinetic/pharmacodynamic analysis of adjunc...
- Prognosis of status epilepticus in elderly patients
- Seizures, CSF neurofilament light and tau in patie...
- Serial electrophysiology in Guillain-Barré syndrom...
- Real-life clinical use of natalizumab and fingolim...
- IJMS, Vol. 18, Pages 2547: Nodule-Enriched GRETCHE...
- Termination of reentrant atrial tachycardia via op...
- Functions of the multi-interacting protein KIDINS2...
- Serial lipase for pancreatitis: not enough evidence
- Correction to: Heavy metal and nutrient uptake in ...
- Phantom validation of quantitative Y-90 PET/CT-bas...
- Management of hereditary breast and ovarian cancer
- A Ra dial Pi llar D evice (RAPID) for continuous a...
- First practical synthesis of novel 1-phosphonylate...
- A new cyclic telluride. Synthesis and reactions of...
- A DFT study of O2 and Cl2 adsorption onto Al12N12 ...
- C-O and C-S coupling reaction of 1,2-di(pyrimidin-...
- Alkylation of 9-substituted guanine derivatives wi...
- Effect of Xylan Sulfates on Coagulation of Human B...
- Pirfenidone-induced hyponatraemia: insight in mech...
- Puff laddy: a 5-year-old-boy with forehead swelling
- Dying art of a history and physical: pulsatile tin...
- Rare and unusual case of perforated appendicitis i...
- Fish hook injury: an easy removal using the string...
- Paediatric Salter-Harris type IV injury of distal ...
- Lesion in the external auditory canal: an unusual ...
- Cancer-related microangiopathic haemolytic anaemia
- Clinical consequences of upfront pathology review ...
- Pirfenidone-induced hyponatraemia: insight in mech...
- Puff laddy: a 5-year-old-boy with forehead swelling
- Dying art of a history and physical: pulsatile tin...
- Rare and unusual case of perforated appendicitis i...
- Fish hook injury: an easy removal using the string...
- Paediatric Salter-Harris type IV injury of distal ...
- Cancer-related microangiopathic haemolytic anaemia
- Delayed presentation of iatrogenic bladder perfora...
- Tuberculosis in Pap Samples with Emphasis on LBC: ...
- Cysticercosis and cytodiagnosis
- A comparison of results of empirical studies of su...
- Rhabdomyolysis, lactic acidosis, and multiple orga...
- Rhabdomyolysis, lactic acidosis, and multiple orga...
- Mycotic pseudoaneurysm of a pulmonary artery branc...
- Analysis of the characteristics of cracked teeth a...
- The costs and benefits of water fluoridation in NZ
- Nickle(II) ions exacerbate bleomycin-induced pulmo...
- Heterogeneous activation of peroxymonosulfate by h...
- Scutellarin alleviates lipopolysaccharide-induced ...
- Characteristics of the trace elements and arsenic,...
- Variations of radon concentration in the atmospher...
- Efficacy and safety of the “Xingnao Kaiqiao” acupu...
- An integrated digital/clinical approach to smoking...
- Sustained inflations versus UK standard inflations...
- Editorial Board/Aims and Scope
- Dengue vaccine supplies under endemic and epidemic...
- Effect of dendritic cell-cytokine-induced killer c...
- A guide to virtual reality da Vinci simulators
- 2017 TERMIS - Americas; Conference & Exhibition; C...
- Abstract Author Index; by abstract number
- Development of a high-resolution infrared thermogr...
- Life course evolution of body size and breast canc...
- Examining tRNA 3-ends in Escherichia coli: A teamw...
- Safety and Pharmacokinetics of the Aminomethylcycl...
- The ABC of biofilm drug tolerance: The MerR-like r...
- Azithromycin Pharmacodynamics against 'Persistent ...
- Increasing antimicrobial resistance in non-typhoid...
- A simple in vitro assay to evaluate the incorporat...
- Efficacy of novel anti-staphylococcal ectolysin P1...
- On the antibacterial and sterilizing effect of ben...
- Preconditioned Augmented Lagrangian formulation fo...
- Cell-Autonomous Metabolic Reprogramming in Hypoxia
- Postnatal myocardium remodelling generates inhomog...
- Hepatitis B reactivation and outcomes in persons t...
- Sofosbuvir and velpatasvir with or without voxilap...
- The Walking Dead: sequential nuclear and organelle...
- miR-221/222 cluster expression improves clinical s...
- Selective N-mono-alkylation of 6-aminouracils with...
- Perioperative, spatiotemporally coordinated activa...
- miR-139-5p modulates radiotherapy resistance in br...
- A potent, metabolically stable tubulin inhibitor t...
- Distinct TP63 isoform-driven transcriptional signa...
- New mechanisms of resistance to MEK inhibitors in ...
- Vitamin C sensitizes melanoma to BET inhibitors
- Utility of single cell genomics in diagnostic eval...
- SHMT2 desuccinylation by SIRT5 drives cancer cell ...
- MYC targeted long non-coding RNA DANCR promotes ca...
- ER alpha binding by transcription factors NFIB and...
- Small molecule inhibition of Axl targets tumor imm...
- YAP1 and COX2 coordinately regulate urothelial can...
- Synthetic lethality of PARP inhibitors in combinat...
- Small cell carcinomas of the bladder and lung are ...
- Classifying colorectal cancer by tumor location ra...
- Honokiol Radiosensitizes Squamous Cell Carcinoma o...
- Cell-Free DNA and Circulating Tumor Cells: Compreh...
- t-Darpp activates IGF-1R signaling to regulate glu...
- Novel BAFF-receptor antibody to natively folded re...
- Breast MRI as a Problem-solving Study in the Evalu...
- Model-based Iterative Reconstruction in Low-radiat...
- CT Features of Hepatic Veno-occlusive Disease
-
▼
Νοε 27
(377)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου