Enhanced Mechanical and Helical Properties with Achiral Calix[4]arene in Co-Assembled Hydrogel which Exhibited the Helical Structure

A mixture of the building blocks 1A and 2G having D-alanine moieties and glycine-functionalized calix[4]arene moieties, respectively, formed co-assembled hydrogel. In particular, the remarkable enhancement of helical intensity of co-assembled gel was controlled by achiral calix[4]arene 2G, which was attributed the bridge effect helically between 1A and 2G like helical structure. Furthermore, the improvements of mechanical strength (G´ and G" values) of co-assembled hydrogel prepared with 1.0 equiv. of 2G were ca. 7000% and ca. 4400% as compared to the gel prepared from the 0.25 equiv. of 2G, respectively. The improved mechanical strength was attributed to the formation of network structure with the H-bonding interaction between 1A and 2G. The results indicate that the helical and mechanical strength enhanced of co-assembled gel could be controlled by achiral component 2G.

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