Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only display excellent DNA binding properties, but also are endowed with new properties not found in their natural counterparts. Here we review some of the developments in the field of artificial peptide-based DNA binders, focusing on the supramolecular and molecular design aspects of such systems.
Researchers have for many years tried to develop sequence-specific DNA-binding peptides that can reproduce the recognition properties of natural transcription factors. We present a historical perspective of those efforts from a supramolecular perspective.
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