Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI

Publication date: Available online 23 November 2017
Source:Academic Radiology
Author(s): Wei Zha, Stanley J. Kruger, Robert V. Cadman, David G. Mummy, Michael D. Evans, Scott K. Nagle, Loren C. Denlinger, Nizar N. Jarjour, Ronald L. Sorkness, Sean B. Fain
Rationale and ObjectivesTo determine lobar ventilation patterns in asthmatic lungs with hyperpolarized ³He magnetic resonance imaging (HP ³He MRI).Materials and MethodsEighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma) underwent HP ³He MRI, computed tomography (CT), and pulmonary function testing. After registering proton to ³He images, we segmented the lungs from proton MRI and further segmented the five lung lobes (right upper lobe [RUL], right middle lobe [RML], and right lower lobe [RLL]; left upper lobe and left lower lobe [LLL]) by referring to the lobar segmentation from CT. We classified the gas volume into four signal intensity levels as follows: ventilation defect percent (VDP), low ventilation percent, medium ventilation percent, and high ventilation percent. The local signal intensity variations in the ventilated volume were estimated using heterogeneity score (Hs). We compared each ventilation level and Hs measured in the whole lung and lobar regions across the three subject groups.ResultsIn mild-to-moderate asthma, the RML and RUL showed significantly greater VDP than the two lower lobes (RLL and LLL) (P ≤ .047). In severe asthma, the pattern was more variable with the VDP in the RUL significantly greater than in the RLL (P = .026). In both asthma groups, the lower lobes (RLL and LLL) showed significantly higher high ventilation percent and Hs compared to the three upper lobes (all P ≤ .015).ConclusionsIn asthma, the RML and RUL showed greater ventilation abnormalities, and the RLL and LLL were more highly ventilated with greater local heterogeneity. These findings may facilitate guided bronchoscopic sampling and localized airway treatment in future studies.



from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2B7wOhr
via IFTTT