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Πέμπτη 7 Δεκεμβρίου 2017

NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3'-spirocyclic oxindoles via C-F bond cleavage protocol

Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C7CC08048D, Communication
Jun Yan, Kuangxi Shi, Chengtao Zhao, liyuan Ding, Shengsheng Jiang, Limin Yang, Guofu Zhong
A chiral NHC-catalyzed [4+2] cycloaddition of [gamma]-fluoroenals is developed. This catalytically generated nucleophlic [gamma]-carbon via C-F bond cleavage undergoes highly enantioselective cycloaddition (up to >99% ee) to isatins and provides...
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