Publication date: Available online 2 December 2017
Source:Pathology - Research and Practice
Author(s): Jiahui Zhang, Sainan Chen, Wenlie Chen, Yunmei Huang, Ruhui Lin, Meiya Huang, Yinsheng Wu, Liangpu Zheng, Zuanfang Li, Naishun Liao, Jinxia Ye, Xianxiang Liu
Osteoporotic osteoarthritis is a phenotype of osteoarthritis (OA) manifested as fragile and osteoporotic subchondral bone. However, the ultrastructural features of subchondral bone in osteoporosis OA have not been determined. The study was aimed to investigate the ultrastructural dynamic changes of subchondral bone in osteoporotic OA model and how the ultrastructural damage in the subchondral bone caused by osteoporosis deteriorated the cartilage damage in OA. Eighteen rabbits were equally randomized to three groups, including the control, the OA and the osteoporotic OA groups. The structural changes of cartilage were evaluated by HE and safranin-O fast green staining, the Mankin's grading system was used to assess the stage of OA progression. And microstructural or ultrastructural changes in subchondral bone were assessed by micro-computed tomography or by scanning electron microscopy. According to the changes of cartilage histopathology, the OA group was in the early pathological stage of OA while the osteoporotic OA group was in the middle stage of OA based on Mankin's grading system. In addition, the damage of cartilage surface, reduction in the number of chondrocytes and the matrix staining were more increased in the osteoporotic OA group compared to the OA group. Compared to the OA group, the subchondral bone in the microstructure and ultrastructure in the osteoporotic OA group showed more microfracture changes in trabecular bone with more destructions of the tree-like mesh. Moreover, the collagen fibers were random rough with a fewer amount of bone lacunae in subchondral cortical plate in the osteoporotic OA group compared to the OA group. These findings indicated that the subchondral bone ultrastructure in the osteoporotic OA model was characterized by the destruction of the network structure and collagen fibers. The subchondral bone ultrastructural damage caused by osteoporosis may change mechanical properties of the upper cartilage and aggravate OA cartilage. Therefore, early diagnosis and treatment of osteoporosis is of great significance to prevent early OA from further developing osteoporotic OA.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2AYjyPJ
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
▼
2017
(41099)
-
▼
Δεκεμβρίου
(3127)
-
▼
Δεκ 07
(466)
- A recurrent mutation in the KRT17 gene responsible...
- Pregnancy in a patient with Netherton syndrome
- Author Index to Volume 119, 2017
- Development of a brief assessment of activity limi...
- IgG4-related disease presenting as hoarseness and ...
- Effect of inhaled allergens and air pollutants on ...
- Information for Readers
- Table of Contents
- rAsp f 3 and rAsp f 4 are associated with bronchie...
- Instructions for Authors
- Toxocara species exposure, symptoms of asthma, and...
- Editorial Board
- Could calcium channel blockers treat 2 illnesses w...
- Baseline asthma burden, comorbidities, and biomark...
- Increasing our knowledge base of asthma
- Innate lymphoid cells and allergic disease
- Rare cause of periorbital and eyelids lesions: Dis...
- Spectrum and prevalence of reactions to marijuana ...
- Baseline asthma burden, comorbidities, and biomark...
- The clinical role of fractional exhaled nitric oxi...
- Burden of skin pain in atopic dermatitis
- Intraoperative anaphylaxis to bacitracin during sc...
- Dengue hemorrhagic fever complicated with acute li...
- Clinical examination and X-ray: an old approach to...
- Necrotising pneumonia caused by non-PVL Staphyloco...
- Interhemispheric subdural and subarachnoid haemorr...
- Fat embolism: a rare cause of perioperative renal ...
- Perineal aggressive angiomyxoma in a menopausal woman
- An uncommon diagnosis for a recurrent erythematous...
- Development of forced normalisation psychosis with...
- Pleural lipoma clinically mimicking the presentati...
- Pulmonary embolism caused by thrombin-based haemos...
- Acute pancreatitis following oesophagogastroduoden...
- Hypersomatotropism induced secondary polycythaemia...
- Inguinoscrotal herniation of a caecal adenocarcinoma
- Double duodenal perforation following foreign body...
- Novel use of a trabecular metal spacer in the trea...
- One long umbilical cord, four nuchal cord loops an...
- Catastrophic catheter-induced coronary artery vaso...
- Treating patients with brain metastases has evolve...
- Lingual dyskinesia in hyperthyroidism
- Cutaneous leishmaniasis mimicking dactylitis in a ...
- UK Dermatology specialist trainee career intentions
- Comparison of transcanal endoscopic tympanoplasty ...
- Is an endoscopic or a microscopic approach optimal...
- Anti-cytokine autoantibodies in a patient with a h...
- Autophagy deficiency in myeloid cells exacerbates ...
- Fatigue in Psoriasis: A Controlled Study
- rAsp f 3 and rAsp f 4 are associated with bronchie...
- Clinical Indicators of the Need for Telemetry Post...
- Intrathecal Morphine for Laparoscopic Segmental Co...
- Anti-mumps IgM antibody positive rate with sudden ...
- Improving patient safety during procedural sedatio...
- Is an endoscopic or a microscopic approach optimal...
- Comparison of transcanal endoscopic tympanoplasty ...
- Live cell imaging reveals different modes of cytot...
- Extensive phenotyping of the orofacial and dental ...
- How bariatric surgery affects liver volume and fat...
- Laparoscopic removal of retroperitoneal tumor with...
- The SAGES Fundamental Use of Surgical Energy progr...
- The role of nonautologous and autologous adipose-d...
- Novel Transforming Glue Treats Emergency Battlefie...
- Multi-agent chemotherapy in advanced soft tissue s...
- Orthodontics contest shows students can sculpt mor...
- Unconscious cognitive dysfunction in emotion dysre...
- The effect of the high-approach versus low-approac...
- Fluid intelligence relates to the resting state am...
- Effects of gynosaponin TN-2 on L-DOPA-induced cyto...
- Feedback is the breakfast of champions: the signif...
- Punishment eliminates directed forgetting: an even...
- Multiple pathological mechanisms contribute to hip...
- When the body becomes no more than the sum of its ...
- Overexpressed wild-type superoxide dismutase 1 exh...
- Simultaneous Speciation Analysis of Arsenic, Chrom...
- Analysis and Classification of the Nasal Base Usin...
- Masseteric Nerve Transfer for Facial Nerve Paralysis
- Peak Nasal Inspiratory Flow as an Objective Measure
- Length of Stay for Free Tissue Transfer to Head an...
- Discrimination threshold for haptic volume percept...
- Flow-assisted Dielectrophoresis: A Low Cost Method...
- Live-imaging of Breast Epithelial Cell Migration A...
- The Bidirectional, Absorbable, No-Drain Abdominopl...
- Superomedial Pedicle Vertical Scar Breast Reductio...
- Can we better predict the biologic behavior of inc...
- Texas fire department welcomes first firefighter-p...
- Seroprevalence of orf infection based on IgM antib...
- SPECT/CT: Looking Beyond Sentinel Lymph Node Ident...
- Protein Expression of PTTG1 as a Diagnostic Biomar...
- Real-Ear Measures
- Quick and Selective Dual Mode Detection of H2S Gas...
- Anatomical study of medial sural artery and its pe...
- Long-Term Survival of Recurrent Intrahepatic Chola...
- Helicobacter pylori induces CDX2 and COX2 expressi...
- Combined Annotation Dependent Depletion (CADD) Sco...
- Breast cancer: The translation of big genomic data...
- The 2016 revision of the WHO Classification of Cen...
- Long-term safety of subcutaneous immunotherapy wit...
- NHC-catalyzed [4+2] cycloaddition reactions for th...
- Base-Catalyzed Thio-Lactamization of 2-(1-Arylviny...
- Sample preparation for polar metabolites in bioana...
-
▼
Δεκ 07
(466)
- ► Σεπτεμβρίου (2173)
-
▼
Δεκεμβρίου
(3127)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Πέμπτη 7 Δεκεμβρίου 2017
Ultrastructural Change of the Subchondral Bone Increases the Severity of Cartilage Damage in Osteoporotic Osteoarthritis of the Knee in Rabbits
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου