Lipid bilayer composition modulates the unfolding free energy of a knotted {alpha}-helical membrane protein [Biophysics and Computational Biology]

α-Helical membrane proteins have eluded investigation of their thermodynamic stability in lipid bilayers. Reversible denaturation curves have enabled some headway in determining unfolding free energies. However, these parameters have been limited to detergent micelles or lipid bicelles, which do not possess the same mechanical properties as lipid bilayers that comprise...

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