PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability [Biochemistry]

Maintenance of genome integrity is critical for both faithful propagation of genetic information and prevention of mutagenesis induced by various DNA damage events. Here we report cold-inducible RNA-binding protein (CIRBP) as a newly identified key regulator in DNA double-strand break (DSB) repair. On DNA damage, CIRBP temporarily accumulates at the...

http://ift.tt/2EW1GXR