Broad spectrum and safety of oral treatment with a promising nitrosylated chalcone in murine leishmaniasis [PublishAheadOfPrint]

The oral efficacy and safety of a leishmanicidal nitro-chalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and L. infantum. Although ten-fold higher doses of CH8 were needed to produce the same antiparasitic effect as the reference drug miltefosine, the later was nephrotoxic, while CH8 restored disease toxicity markers to normal. This study shows the therapeutic potential of an orally active and hepato/nephroprotective chalcone against both cutaneous and visceral leishmaniasis.

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