Publication date: Available online 21 February 2019
Source: Journal of Allergy and Clinical Immunology
Author(s): Oliver P. Skinner, Julie Jurczyluk, Paul J. Baker, Seth L. Masters, Alicia Rios Wilks, Misaki S. Clearwater, Avril A.B. Robertson, Kate Schroder, Sam Mehr, Marcia A. Munoz, Michael J. Rogers
Summary
We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.
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