Population Pharmacokinetic Assessment of Vancomycin Dosing in the Large Pediatric Patient [Pharmacology]

The most appropriate vancomycin dosing strategy in pediatric patients weighing ≥70kg (weight based vs non-weight based) to achieve an area under the curve (AUC) ≥400mg*L/hour and a trough concentration < 20mg/L is not known. Population pharmacokinetic analysis determined that vancomycin should be weight based dosed using fat free mass, with appropriate adjustment for kidney dysfunction.

http://bit.ly/2GFnrLZ