Surveillance for familial melanoma: recommendations from a national centre of expertise

Abstract

An estimated 10% of patients diagnosed with melanoma have a positive family history for this cutaneous malignancy. Familial melanoma is arbitrarily defined as the occurrence of three or more melanomas in multiple members of a family, at least two of which are diagnosed in first‐degree relatives. The pedigrees of these families are compatible with an autosomal dominant mode of inheritance. In a subset of families clustering is caused by polygenic inheritance or shared ultraviolet radiation exposure patterns among members.

This article is protected by copyright. All rights reserved.

http://bit.ly/2DppeS0