Zinc depletion does not necessarily induce ribosome hibernation in mycobacteria [Biological Sciences]

In PNAS, Li et al. (1) recently reported analysis of Mycobacterium smegmatis ribosomes formed under zinc-limited conditions. A zinc chelator [N,N,N′,N′-tetrakis(2-pyridylmethyl)-ethylenediamine] was added to growth medium and an extended purification procedure was employed to obtain zinc-depleted (C−) ribosomes for cryo-EM. The structure was solved at 3.5-Å resolution and showed five...

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