Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed [Biophysics and Computational Biology]

Early embryogenesis of most metazoans is characterized by rapid and synchronous cleavage divisions. Chemical waves of Cdk1 activity were previously shown to spread across Drosophila embryos, and the underlying molecular processes were dissected. Here, we present the theory of the physical mechanisms that control Cdk1 waves in Drosophila. The in...

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