Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in {beta}-arrestin coupling [Biochemistry]

The ability of G protein-coupled receptors (GPCRs) to initiate complex cascades of cellular signaling is governed by the sequential coupling of three main transducer proteins, G protein, GPCR kinase (GRK), and β-arrestin. Mounting evidence indicates these transducers all have distinct conformational preferences and binding modes. However, interrogating each transducer's mechanism...

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